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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Liquid Chromatography: Analysis of Sunscreen Active Ingredients

  
  
  
  
  
  

analysis of sunscreen ingredients in one injectionDoesn't the fabulous image of this carefree child invite you to head to the beach and get some sun right now? Being in the sun during the summer is one of the joys of living in the Northern Hemisphere for many of us, myself included! And, of course wearing sunscreen is one of the rituals in the summer besides being constantly drummed into all of us. (Google the words "importance of sunscreen").

Here is a great webpage on the importance of sunscreen and cancer prevention.

Here, we present two applications on the analysis of active ingredients in sunscreen-containing products with the second method improving the first method!

Application Note 223, Determination of Ten Active Ingredients in Sunscreen-Containing Products in a Single Injection, (downloadable PDF) was developed on the request of a sunscreen manufacturer and describes the baseline resolution of 10 compounds used in sunscreen in a single injection. The compounds include 2-phenyl-benzimidazole-5-sulfonic acid, benzophenone-3, diethylamino-hydroxybenzoylhexyl benzoate, 4-methylbenzylidine-camphor, octocrylene, methylanthranilate, octyl-methoxycinnamate, butylmethoxydibenzoylmethane, octyl-salicylate, and homosalate.

The method used a 3-μm reversed-phase LC column (Thermo Scientific Acclaim 120 C18 column) with our liquid chromatography (LC) system (Thermo Scientific Dionex UltiMate 3000 system) and resolved all 10 compounds in less than 12 min. By the way, the same method  also successfully determined subsets of these 10 compounds in a lipstick, a cosmetic powder, and a lotion.

Application Brief 113, Fast Separation of Twelve Active Ingredients Used in Products Containing Sunscreen, (downloadable PDF) adds two active sunscreen ingredients that were not analyzed in Application Note 223: benzophenone-4 and ethylhexyl triazone. The method was also transferred to the Rapid Separation Liquid Chromatography (RSLC) system (Thermo Scientific Dionex UltiMate 3000 RSLC system) and a 2.2 μm reversed-phase LC column (Acclaim RSLC 120 C18, 2.1 × 100 mm column). The separation of the 12 compounds was faster than the separation of the 10 ingredients in AN 223 and also required less than half the eluent!

Let us know of your testing challenges in sunscreen-containing products. Our experts will be pleased to answer your questions.

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