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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Capillary IC & Mass Spectrometry for Trace Environmental Analysis


With Dionex Ion Chromatography (IC) becoming a part of Thermo Fisher Scientific, and with the introduction of capillary IC, the usability of IC with mass spectrometry (MS) for trace-level analysis and sample-size-limited research has been significantly enhanced.

Here, we present a method for capillary IC with Reagent-Free IC (RFIC) -MS with our capillary Reagent-Free IC (RFIC) system (Thermo Scientific Dionex ICS-5000 RFIC system) with suppression technology which converts the MS-incompatible mobile phase to deionized (DI) water, and a modified electrospray ionization (ESI) source which optimizes capillary flow sensitivity. This method provides applications for trace level environmental analysis, including common anions and organic acids, perchlorate, and residue of the herbicide endothall in environmental water samples.

The workflow for Capillary IC-MS is displayed in the flow diagram below.

Trace Elemental Analyis using Capillary IC & MS


Poster, Capillary Ion Chromatography Mass Spectrometry for Trace Environmental Analysis, (downloadable PDF) demonstrates the confirmation and sensitive quantitation of the following anions all within 10 mins in environmental waters:

  • Anions fluoride, chloride, nitrate, sulfate, and phosphate
  • Organic tartaric acid
  • Herbicide endothall
  • Perchlorate at a 10 parts-per-trillion

Let us know if this blog post was helpful to you! Also, don't forget to mention if you are interested in other applications using our Capillary IC-MS solution. We look forward to hearing from you!


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