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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Monoclonal Antibody High-Resolution Separations Using HIC

hic analysis of monoclonal antibodies

A few weeks ago, I featured a method for the analysis of monoclonal antibodies (MAbs) on a recently released hydrophobic interaction chromatography (HIC) column (link to post) and, here, I am pleased to feature another method on another newly released HIC column (Thermo Scientific MAbPac HIC-10 column)! This new column is a high-resolution, silica-based HIC column designed for separation of mAbs and variants, including anti-body conjugates (ADCs) and provides high resolution, excellent bio-compatibility, and selectivity as compared to HIC columns on the market.

Sample Preparation & LC-MS Analysis: Pharma & Nanomaterials in Water

analysis of Nanomaterials in Water

Do you know that nanomaterials (down to 10,000 smaller than the diameter of a human hair) can be natural (viruses, wax crystals on a lotus leaf, spider silk, butterfly wing scales, blood, milk) or manufactured? (link and source Wikipedia.) Manufactured nanoparticles are increasingly being used in pharma drug delivery, disease detection, energy production, and even food and have triggered growing concern regarding their environmental behavior in aquatic environments. The ability to detect and quantify nanomaterials in complex water matrices has become an important issue (link to EU nanomaterials webpage).

GC-MS/MS Workflows for Metabolomics Experiments

gc-ms metabolite analysis

Did you know that there are up to 5 million metabolites (link to Wikipedia) in the plant kingdom? As a result, the identification and monitoring of these compounds can be extremely challenging. Here, I am pleased to present a couple of resources on the use of gas chromatography-mass spectrometry techniques that can increase the number of identifiable and selectively quantifiable metabolites by combining analytical methods for the different phases of the analysis. (By the way, previously I had written about the use of capillary ion chromatography and HR/AM for the metabolite profiling of oral cancers.)

Capillary Ion Chromatography & HR/AM: Metabolite Profiling of Cancer

chromatography analysis of cancer polar metabolites

Did you know that metabolomics (systematic study of the unique chemical fingerprints that specific cellular processes leave behind) is increasingly used in the study of oral cancers? (Definition: Wikipedia)

HPLC Solid-Core Columns For Fast Pharma Analysis (I)

hplc pharma analysis columns

A two-part series on several resources for our solid-core HPLC columns has been on my to-do list for a while now and kept getting pushed back down the list every week until I decided that I simply had to write about them. So, here goes.

Ion Chromatography Speeds Petroleum Refinery Analysis (I)

analysis of amines in oil and gas

I am pleased to feature a 3-part series on our chromatography solutions for the analysis of light, middle, and heavy distillates in petroleum production and scrubber solutions and boiler/cooling water used in petroleum industrial processes. Solutions include our ion chromatography, gas chromatography, liquid chromatography, ICP-OES, GC-ICP-MS, and combustion ion chromatography applications and analytical instruments.

Novel HPLC Approaches for Carbohydrate Analysis in Beverages & Food

Carbohydrate Analysis in Beverages & Food

Recently, we partnered with to present a webinar on the use of universal Charged Aerosol Detection and selective pulsed amperometric detection for the direct determination of carbohydrates in complex food and beverage matrices. The advantages of two novel approaches, HPAE-PAD and HILIC-CAD was also discussed. The attendees asked several interesting questions on the types of detection and I thought they would make for good reading along with a couple of other resources.

Challenges of Intact Protein LC-MS Work: On-Demand Webinar

intact protein separations

I just realized that it has been a long time since I wrote about a proteomics application on this blog and the on-demand LC-MS webinar featured here fits the bill! The goal of the webinar is that by the end of the webinar, the participant will be able to perform foolproof intact protein analysis, regardless of their expertise in this area.

Reagent-Free Ion Chromatography Water Analysis: On-Demand Webinars

analysis of wastewater drinking water high-purity water

Did you know that only 47.4% of surface water in China's water bodies meets usable water quality standards and recently, the government has announced a crackdown on illegal wastewater discharges? (Link to story.) Here, I am pleased to present to you three on-demand webinars (no registration necessary) featuring simple water quality analysis methods using the latest ion chromatography innovations!

Chromatography Vial Identification System: On-Demand Webinar

chromatography vials

Last month, I had presented our new chromatography vial identification system (Thermo Scientific Virtuoso Vial Identification System) in a blog post, titled, Chromatography Vial Identification System Launched!, and, here I am pleased to feature an on-demand webinar on the system that will help you learn more about the system in a quick and easy way. The reason this topic has been on my mind a bit is because we have received questions from chromatographers asking what type of workflow errors that can result from manual labeling of vials.

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