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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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HPLC Toxiology Research Articles on Analysis of Illicit Drugs

  
  
  
  
  
  
hplc toxicology analysis

I have mentioned before on this blog that I am fascinated by the subject of toxicology and find peer-reviewed articles featuring the use of chromatography, such as the two articles featured here, absolutely riveting. By the way, did you know that the pace at which new and illicit psychoactive substances have been emerged has speeded up tremendously in the last few years?

Automated Solid Phase Extraction & GC Analysis of Pesticides in Water

  
  
  
  
  
  
analysis of organophosphate pesticides

Did you know that the U.S. EPA posts annual reports on quality of drinking water by state? (Link to U.S. EPA site.) Does the regulatory entity responsible for monitoring water quality in your country do so? If yes, do share the link to its site in the Comments box below.

HPLC Method for Determination of Benzo(a)pyrene in Meat Products

  
  
  
  
  
  
Benzo(a)pyrene in smoked meat

Here, I am pleased to present an efficient HPLC method featuring an improved sample preparation method with fluorescence detection for the sensitive and rapid determination of benzo[a]pyrene (downloadable U.S. EPA factsheet) in complex meat products, such as sausages and preserved ham. 

Scaling Down Sample Extraction for Limited & Volatile Sample Volumes

  
  
  
  
  
  
bioanalysis sample preparation

In an earlier post on the use of our recently released solid-phase extraction (SPE) micro elution plates (Thermo Scientific SOLAµ Solid Phase Extraction [SPE] Well Plates) for bioanalysis, I covered how these well plates can enhance sample concentration by 20X (link to post), and here I am pleased to present an application note on how these plates can be used to facilitate the scale down of an extraction method for use when sample volume is limited or volatile as in the case of bioanalytical samples.

Sample Preparation for Analytes Susceptible to Degradation or Loss

  
  
  
  
  
  
bioanlysis sample preparation

Here is the third application note in this series on improving sample preparation for bioanalytical and clinical research applications using our recently released solid-phase extraction (SPE) micro elution plates (Thermo Scientific SOLAµ Solid Phase Extraction [SPE] Well Plates). The previous two application notes are presented in the following blog posts:

HPLC SPE Well Plates Enhance Sample Concentration by 20X

  
  
  
  
  
  
sample preparation HPLC

Last month, I featured our recently released solid-phase extraction (SPE) micro elution plates (Thermo Scientific SOLAµ Solid Phase Extraction [SPE] Well Plates) designed specifically for sample preparation for bioanalysis experiments in a blog post, titled, Solid-Phase Extraction (SPE) Micro Elution Plates for Bioanalysis and, here, I am pleased to present a recently application note featuring the use of these well plates.

Solid Phase Extraction (SPE) Micro Elution Plates for Bioanalysis!

  
  
  
  
  
  
Solid Phase Extraction plates for bioanalysis

I am pleased to feature our recently released solid phase extraction (SPE) micro elution plates (Thermo Scientific SOLAµ Solid Phase Extraction (SPE) Well Plates) designed specifically for bioanalysis experiments. Bioanalysis is moving toward methods that require higher levels of sensitivity and reproducibility with decreasing sample volumes.

SPE & LC-MS/MS Analysis of Cancer Drug Doxorubicin in Human Plasma

  
  
  
  
  
  
hplc analysis of Doxorubicin

Did you know that the cancer drug Doxorubicin is derived from a bacterial species by chemical semisynthesis and is used to treat a wide range of cancers? (Link & source Wikipedia). A pegylated liposomal formulation of doxorubicin is used in cancer treatment and it is essential to establish a fast and robust LC-MS/MS method for separation and determination of liposomal and non-liposomal (free) doxorubicin present in circulating blood.

Automated SPE Speeds GC Analysis of Pesticides in Beverages

  
  
  
  
  
  
GC Analysis of Pesticides in fruit drinks

The poster featured in this blog post has a somewhat funny title which caught my eye when I was reviewing the list of the latest and most popular gas chromatography applications from one of our marketing specialists. The other reason I am writing about this application is because it does seem concerning that a study from Spain (referenced in the poster) found that pesticides in fruit-based soft drinks are 300 times higher than those in tap water (link to study).

SPE and LC-MS/MS Method: Analysis of Vitamin D in Human Plasma

  
  
  
  
  
  
Analysis of Vitamin D metabolites in Human Plasma

After the last post on the use of gas chromatography-mass spectrometry in bioanalysis research studies (link to post), I am pleased to feature a recently released solid-phase extraction (SPE) and LC-MS/MS method for the analysis of the sunshine vitamin, Vitamin D, in human plasma.

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