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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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A Milestone in Pesticides Analysis for Orbital Trap Mass Spectrometry


Sample Preparation: Three Techniques Reviewed

hplc sample preparation

I hope you found the last installment on Hydrophobic Interaction Liquid Chromatography (link to blog post) useful. Supporting my goal to discuss and provide resources on the latest tools and techniques that will help improve and speed up your day-to-day work in the lab, I will discuss sample preparation for HPLC in this post.

GC-MS & GC-ECD Methods for Pesticides in Fruit & Tea Research Studies

gc-ecd pesticides in tea

Here, I am pleased to present two research studies describing the use of gas chromatography-mass spectrometery (GC-MS) and gas chromatography-electro capture dectectorchemical (GC-ECD) for the analysis of pesticides in strawberries and tea respectively. Sounds like a lovely English afternoon doesn't it except for the pesticides bit. Did you know that 80% of the strawberries in the United States are supplied by one state, that is, California? Here's a comprehensive read on all you ever wanted to know about strawberries from how they are grown, why are they getting bigger and yet less flavorful, and what organic strawberries actually mean: The Secret Life Of California's World-Class Strawberries (link to article).

GC-MS/MS Speeds Analysis of 200 Pesticides in Ayurvedic Churna

analysis of ayurvedic medicines

In the fascinating application presented in this blog post, chemists from our Mumbai (India) and Singapore labs collaborated on the development of a fast and precise GC-MS/MS method for the routine determination of multi-residue pesticides in Indian Ayurvedic medicine churna, a blend of ground spices and herbs.

LC-MS/MS & QuEChERS Determines 24 Pesticide Residues in Red Wine

analysis of pesticide residues in red wine

Did you read about the recent discovery of a 3,700-year old wine cellar in Israel with what turns out to be sophisticated wine? As I read details about how chemical analysis is indicating the presence of mint, cinnamon, resins, and honey among other ingredients in the wine, my mind immediately thought of the idea of palace banquets of that time with wine connoisseurs inhaling the wine bouquet and sipping it while trying to analyze the wine in a manner similar to wine tastings today!

HPLC/UHPLC-MS: Customer Solutions for Food Additives & Contaminants

food additives and contaminants

The focus for the October 2011 issue of the Food Additives and Contaminants journal was applications for liquid chromatography (LC) and high-resolution Mass Spectrometry (MS) in food safety and it has five peer-reviewed customer articles featuring our instruments! Normally, this journal allows subscribers to view articles online only so we purchased copies of the articles so that they can downloaded for free online. The articles will be available for downloading until March 1, 2012 so if you are interested, please go to the links below and download.

GC-MS Analysis of Pesticides using QuEChERS Extraction

Pesticides in Tea

Question: If you had a lot food of samples to extract and not a lot of time or money to do it, how would you extract?

Our answer: Since we didn’t have a lot of time, room, or additional funding we used the QuEChERS technique.

David Steiniger, Senior MAD Scientists in the lab, worked with the procedure as written and adjusted it into something that we could use with the Ion Trap GC/MS system.  It also worked ridiculously well with the Triple Quadrupole GC/MS. The quechers flowchart, in the attached file, that he came up with simplified the process to the point where even the MAD MANager could do it, that would be me.

Now that the samples are extracted the question is how would you analyze the samples?  In the case of these four matrices, onion, lettuce, rice, and tea we chose an Ion Trap GC/MS.  This technology were chosen because there was a limited number of matrices and we knew the list of pesticides that would be on each crop, that number was below 60.

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