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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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HPLC Applications Notebook: Traditional Chinese Medicine

  
  
  
  
  
  
Traditional Chinese Medicine HPLC analysis

Did you know that the oldest work on Traditional Chinese Medicine (TCM) appeared in 200 B.C. and that the first TCMs and acupuncture needles appeared around 2500 BCE in China? (Link to site.) And, here I am pleased to present to you our recently released notebook featuring HPLC applications for TCM to help ensure the efficacy, purity and safety of these traditional remedies!

Electrochemical Detection Troubleshooting

  
  
  
  
  
  
troubleshooting Electrochemical Detection (ECD)

I came across two technical notes on troubleshooting Electrochemical Detection (ECD) problems, featured in this blog post, while reading up on a recently released HPLC application that used this type of detection. And, soon after, I found a poster note on the topic and thought this would make for a useful read for those working in HPLC-ECD applications. For those new to this type of detection, ED is the most sensitive and selective mode of LC detection for the measurement of oxidizable or reducible compounds.

Monoclonal Antibody Characterization: Technical Guide on Columns

  
  
  
  
  
  
hplc Monoclonal Antibody Characterization

I am pleased to present here our recently released Biomolecules Technical Guide (downloadable PDF) on the HPLC column best suited to Monoclonal Antibody (mAb) characterization. If you work in this field, you will be aware that mAb treatment is one of the most effective methods of diagnosis and treatment of a broad range of diseases, including autoimmune disorders, cardiovascular diseases, infectious diseases, cancer, and inflammation. And, since there is an extensive development pipeline for protein and mAb therapeutics, there is a need for innovative and efficient analytic tools.

LC-MS Solutions for Analysis of Marine Biotoxins in Shellfish

  
  
  
  
  
  
hplc analysis of marine biotoxins in shellfish

Did you know that marine biotoxins resulting from algal blooms can accumulate in bivalve mollusks as these organisms filter large quantities of water and can poison human beings who consume the mollusks? For example, in the State of New York (USA), one can check the sanitary conditions of shellfish lands and find out if they are closed for shellfish collection (link to site). Studies have shown that phosphorus in agricultural fertilizer is the primary cause of toxic algal blooms, as in the Great Lakes in the USA (link to article).

Chromatography for Neuroscience Applications Notebook

  
  
  
  
  
  
hplc neuroscience analysis

I am pleased to feature an interactive, downloadable applications notebook featuring the use of our UHPLC-ready systems along with our highly sensitive and selective detectors, column technologies, and software in neuroscience research. Using our UHPLC-ready solutions, you will be able to:

HPLC Method Speeds Analysis of Polycyclic Aromatic Hydrocarbons

  
  
  
  
  
  
analysis of polycyclic aromatic hydrocarbons in water

I am pleased to present a recently released high-performance liquid chromatography method to determine 20 polycyclic aromatic hydrocarbons (PAHs) in environmental waters using online solid-phase extraction (SPE) for sample preparation. This approach moves the offline sample preparation procedures of U.S. EPA Method 550 and EPA Method 550.1 online to save time and labor.

Charged Aerosol Detection of Surfactants in mAb Formulation

  
  
  
  
  
  
Surfactant analysis in Monoclonal Antibody Formulation

This post briefly presents a very recently released research study featuring the use of our Charged Aerosol Detector (CAD) and two elegant UHPLC-CAD-MS methods for the analysis of polysorbate 20 in monoclonal antibody (mAb) formulation. (Image is of an Immunoglobulin G, IgG1, mAb molecule.)

HPLC & UHPLC Instrument Troubleshooting Solution!

  
  
  
  
  
  
hplc uhplc troubleshooting

I am pleased to present a very recently released HPLC and UHPLC troubleshooting solution (Thermo Scientific XPert Troubleshooting Solution) to address issues, such as questionable assay results, out-of-control situations, deviation in instrument or column, preventative maintenance, column replacement, and application fine tuning for our dedicated HPLC and UHPLC instruments (Thermo Scientific Dionex UltiMate 3000 System) configurations.

Chromatography Vial Identification System: On-Demand Webinar

  
  
  
  
  
  
chromatography vials

Last month, I had presented our new chromatography vial identification system (Thermo Scientific Virtuoso Vial Identification System) in a blog post, titled, Chromatography Vial Identification System Launched!, and, here I am pleased to feature an on-demand webinar on the system that will help you learn more about the system in a quick and easy way. The reason this topic has been on my mind a bit is because we have received questions from chromatographers asking what type of workflow errors that can result from manual labeling of vials.

HPLC & UHPLC Research Studies in Traditional Chinese Medicine (II)

  
  
  
  
  
  
HPLC methods for Traditional Chinese Medicine

This is part 2 of the two-part series of the five HPLC research studies describing fast and improved methods for the analysis of Traditional Chinese Medicine (TCM). (Part I can be read here: HPLC & UHPLC Research Studies in Traditional Chinese Medicine (I).)

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