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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Importance of Solvent Quality in UHPLC & HPLC Analysis

  
  
  
  
  
  
hplc solvent quality

I am pleased to present a recently released technical note on how to optimize and monitor the quality of your solvents when using UV-Vis absorption, fluorescence detection, or charged aerosol detection with HPLC or UHPLC.

Accelerated Solvent Extraction & UHPLC Analysis of Mangosteens

  
  
  
  
  
  
HPLC analysis of xanthones

The fascinating UHPLC study in this blog post was presented at the recent Pittcon conference and presents a fast extraction method using Accelerated Solvent Extraction (ASE) which requires only 30 mins and provides >96% recovery with excellent reproducibility!

UHPLC and HPLC Methods for Improved Analysis of Peptides

  
  
  
  
  
  
peptide analysis by HPLC

The interesting poster presented in this blog post was presented at the recent Pittcon conference and it describes the development of UHPLC and HPLC electrochemical detection (EC) methods for the measurement of different cystine-containing peptides including simple peptides (glutathione), medium-sized peptides (insulin), cyclic peptides (oxytocin and vasopressin) and peptides with cystine knots (cyclotides). (Image accompanying this post is of an insulin molecule.)

Chromatography Vial Identification System Launched!

  
  
  
  
  
  
chromatography vial labeling

I am pleased to feature our recently released chromatography vial labeling and identification system (Thermo Scientific Virtuoso Vial Identification System) designed to eliminate costly labeling errors and boost productivity!

Speeding Universal Method Transfer from HPLC to UHPLC!

  
  
  
  
  
  
hplc method transfer to uhplc

Can you easily and quickly apply all rules for a successful HPLC-to-UHPLC method transfer? If you are doing this frequently, you are probably doing the math on a piece of paper each time and wasting valuable time; here, we are pleased to present a tool plus a technical note that could help speed things up significantly for chromatographers!

Top 10 Features of a Successful Chromatography Data System!

  
  
  
  
  
  
chromatography  software

I am pleased to share a useful webinar focused on what should be the requirements of a successful chromatography software plus some resources that could help speed up your work.

LC-MS Screening of Banned Drugs in Equinine Blood Samples!

  
  
  
  
  
  
Banned Drug Screening in horse Blood Samples

I recently received notice of the on-demand webinar presented in this blog; the topic of the webinar in how to improve traditional LC-MS drug screening solutions by automating on-line sample cleanup (Thermo Scientific TurboFlow technology) and using our ultra high-resolution liquid chromatography (UHPLC) solution. And, as it is the case many times, I also found a research paper on the subject that I thought would make a useful read on this type of analysis.

Chromatography Solution Online Center Now Open!

  
  
  
  
  
  
liquid chromatography, ion chromatography, gas chromatography, and chromatography software

Do you know about our collaboration with Chromatographyonline.com in presenting an online Chromatography Solution Center to serve as a resource for chemists, scientists, and researchers by presenting the latest developments and applications, in chromatography?

Miniaturization of Liquid Chromatography for Proteomics Analysis

  
  
  
  
  
  
liquid chromatography minitiarization for proteomics

I am pleased to feature a recently released white paper on the theory, principles, and practical implications of miniaturization of liquid chromatography (LC) in the analysis of proteomics, biopharmaceuticals, and forensics/toxicology. It is done to increase the sensitivity of analysis which is necessary in the analysis of low abundant peptides and proteins. Other benefits of miniaturization include improving the efficiency of interfacing with mass spectrometry and reduction of solvent consumption. Nowadays, miniaturized LC is much easier to use and both the instrumentation and the connections are operated in the same way as conventional-scale LC systems. This opens up opportunities to apply miniaturized LC to novel workflows and applications, especially for capillary and micro LC.

UHPLC Methods for Fast Screening in Early Drug Discovery!

  
  
  
  
  
  
HPLC, UHPLC, HILIC, charged aerosol detection

We recently presented a very well-attended webinar on HPLC and UHPLC methodologies for versatile and powerful new pharma solutions featuring the use of our hydophilic interacton liquid chromatography (HILIC) and other reverse phase columns and our latest charged aerosol detector (Thermo Scientific Dionex Corona Veo Charged Aerosol Detector). I also found several excellent resources (an applications guides and two poster notes) to supplement the the information in the webinar and thought it would be useful reading for those working in the field of early drug discovery.

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