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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Next Generation Charged Aerosol Detector Introduced!

  
  
  
  
  
  
charged aerosol detection

Recently, we released our next-generation charged aerosol detector (Thermo Scientific Dionex Corona Veo detector) at this year's HPLC 2013 Symposium in Amsterdam, and I thought it would be a great feature for our blog readers.  The new Corona Veo detector extends the capabilities of our existing charged aerosol detectors by taking advantage of UHPLC and different mobile phase chemistries with the following benefits:

UHPLC Electrochemical Detection in Life Sciences: FAQ (2)

  
  
  
  
  
  
HPLC and UHPLC in life science research

In this Part 2 of the FAQ from our on-demand webinar: Simplifying difficult life science analyses with UHPLC electrochemical detection, (link to registration page) which featured our latest electrochemical detection platform (Thermo Scientific Dionex UltiMate 3000 Electrochemical Detector). Read Part 1 here: UHPLC Electrochemical Detection in Life Sciences: FAQ (1).

SPE-LC-MS/MS: Determination of Nicotine & Metabolites in Urine

  
  
  
  
  
  
analysis of nicotine

I am not a smoker but whenever I see a smoker trying to quit by chewing nicotine gum or by using a patch, the thought does cross my mind as to how does the person know the quantity of  nicotine to ingest without overdosing or getting too little. And, when this application note describing a liquid chromatography tandem mass spectrometry method for nicotine, cotinine, and trans-3-hydroxycotinine in urine came across my desk, I did a little research. The answer turned out to be fairly simple: a smoker's urine is tested for nicotine, cotinine, and trans-3-hydroxycotinine levels and based on the results, nicotine replacement levels are recommended. Nicotine is exerted in the urine plus it metabolizes to cotinine and trans-3-hydroxycotinine in the liver, which are also excreted in the urine.

UHPLC Electrochemical Detection in Life Sciences: FAQ (1)

  
  
  
  
  
  
hplc and uhplc life science research

Recently, we presented a well-attend webinar (now available on-demand), Simplifying difficult life science analyses with UHPLC electrochemical detection, (link to registration page) which featured our latest electrochemical detection platform (Thermo Scientific Dionex UltiMate 3000 Electrochemical Detector).

HPLC Column for Glycan Separation by Size, Polarity, and Charge

  
  
  
  
  
  
glycan analysis

Our recent issue of the BioPharma enewsletter featured a recently released high-resolution HPLC glycan column (Thermo Scientific GlycanPac AXH-1 column) developed for the separation of charged glycans that coelute from conventional amide HILIC columns. This new column can be used for qualitative, quantitative, and structural characterization of uncharged and charged glycans present in biological molecules, such as proteins, by fluorescence detection (Thermo Scientific Dionex UltiMate FLD-3400RS Rapid Separation Fluorescence Detector) or mass spectrometry (MS) detection (Thermo Scientific Q Exactive Benchtop LC-MS/MS) methods.

UHPLC Electrochemical Detection Simplifies Life Science Analysis

  
  
  
  
  
  
chromatography life science research

I am really pleased to present an upcoming, complimentary webinar on the use of UHPLC and electrochemical detection as a technique to mimic biological processes in neuroscience and free radical biology research for life science researchers working in the fields of neuroscience, degenerative diseases, and neuro-active therapeutics.

UHPLC & UV Detection: Fast Separation of 19 Regulated Phthalates

  
  
  
  
  
  
phthalate analysis

Recently, my RSS feed for environmental stories from the continent of Africa presented me with two stories which got me thinking about how all over the world governments are realizing the impact of water quality and pollution on the health of their populations. (The first story was on Zimbabwe suspending seven water bottling firms for poor quality of water and the second story was on the Rwandan government cracking down on industries that do not have water treatment facilities.)

Chromatography Software: Meet Charlie Chromeleon of Version 7.2!

  
  
  
  
  
  
chromatography software

I am pleased to introduce our blog readers to Charlie Chromeleon, the face of our latest Chromatography Data System (CDS) software release! This is an exclusive interview with Charlie and you heard it first here!

HPLC & MS Workflows for Proteomics: 2 On-Demand Webinars

  
  
  
  
  
  
uhplc proteomics

One of our recent enewsletters was focused on HPLC and mass spectrometry solutions for bioapplications and listed two on-demand webinars, featured in this blog post, for improving workflows in proteomics research that I thought would be useful for scientists working in the field.

HPLC & SPE: Catechins and Phenolic Acids in Red Wine

  
  
  
  
  
  
polyphenol analysis

Red wine has been in the news in the last few weeks with two fairly disparate studies, both of which I found fascinating. In the first study, researchers from the Kingston University in London warned that red wine could mask testosterone levels thus mask doping by athletes (link to story) and in the second study, again from the UK, but this time from the University of Leeds, researchers found that extracts from green tea and red wine disrupted Alzheimer disease pathways (link to story).

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