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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Monoclonal Antibody Characterization: Technical Guide on Columns

  
  
  
  
  
  
hplc Monoclonal Antibody Characterization

I am pleased to present here our recently released Biomolecules Technical Guide (downloadable PDF) on the HPLC column best suited to Monoclonal Antibody (mAb) characterization. If you work in this field, you will be aware that mAb treatment is one of the most effective methods of diagnosis and treatment of a broad range of diseases, including autoimmune disorders, cardiovascular diseases, infectious diseases, cancer, and inflammation. And, since there is an extensive development pipeline for protein and mAb therapeutics, there is a need for innovative and efficient analytic tools.

LC-MS Solutions for Analysis of Marine Biotoxins in Shellfish

  
  
  
  
  
  
hplc analysis of marine biotoxins in shellfish

Did you know that marine biotoxins resulting from algal blooms can accumulate in bivalve mollusks as these organisms filter large quantities of water and can poison human beings who consume the mollusks? For example, in the State of New York (USA), one can check the sanitary conditions of shellfish lands and find out if they are closed for shellfish collection (link to site). Studies have shown that phosphorus in agricultural fertilizer is the primary cause of toxic algal blooms, as in the Great Lakes in the USA (link to article).

Chromatography for Neuroscience Applications Notebook

  
  
  
  
  
  
hplc neuroscience analysis

I am pleased to feature an interactive, downloadable applications notebook featuring the use of our UHPLC-ready systems along with our highly sensitive and selective detectors, column technologies, and software in neuroscience research. Using our UHPLC-ready solutions, you will be able to:

HPLC Method Speeds Analysis of Polycyclic Aromatic Hydrocarbons

  
  
  
  
  
  
analysis of polycyclic aromatic hydrocarbons in water

I am pleased to present a recently released high-performance liquid chromatography method to determine 20 polycyclic aromatic hydrocarbons (PAHs) in environmental waters using online solid-phase extraction (SPE) for sample preparation. This approach moves the offline sample preparation procedures of U.S. EPA Method 550 and EPA Method 550.1 online to save time and labor.

Charged Aerosol Detection of Surfactants in mAb Formulation

  
  
  
  
  
  
Surfactant analysis in Monoclonal Antibody Formulation

This post briefly presents a very recently released research study featuring the use of our Charged Aerosol Detector (CAD) and two elegant UHPLC-CAD-MS methods for the analysis of polysorbate 20 in monoclonal antibody (mAb) formulation. (Image is of an Immunoglobulin G, IgG1, mAb molecule.)

HPLC & UHPLC Instrument Troubleshooting Solution!

  
  
  
  
  
  
hplc uhplc troubleshooting

I am pleased to present a very recently released HPLC and UHPLC troubleshooting solution (Thermo Scientific XPert Troubleshooting Solution) to address issues, such as questionable assay results, out-of-control situations, deviation in instrument or column, preventative maintenance, column replacement, and application fine tuning for our dedicated HPLC and UHPLC instruments (Thermo Scientific Dionex UltiMate 3000 System) configurations.

Chromatography Vial Identification System: On-Demand Webinar

  
  
  
  
  
  
chromatography vials

Last month, I had presented our new chromatography vial identification system (Thermo Scientific Virtuoso Vial Identification System) in a blog post, titled, Chromatography Vial Identification System Launched!, and, here I am pleased to feature an on-demand webinar on the system that will help you learn more about the system in a quick and easy way. The reason this topic has been on my mind a bit is because we have received questions from chromatographers asking what type of workflow errors that can result from manual labeling of vials.

HPLC & UHPLC Research Studies in Traditional Chinese Medicine (II)

  
  
  
  
  
  
HPLC methods for Traditional Chinese Medicine

This is part 2 of the two-part series of the five HPLC research studies describing fast and improved methods for the analysis of Traditional Chinese Medicine (TCM). (Part I can be read here: HPLC & UHPLC Research Studies in Traditional Chinese Medicine (I).)

HPLC & UHPLC Research Studies in Traditional Chinese Medicine (I)

  
  
  
  
  
  
HPLC applications for Traditional Chinese Medicine

It has been a while since I have written about herbal medicine applications, the last one was on the GC-MS analysis of pesticides in ayurvedic churna (link to post), and here I am pleased to briefly present five HPLC research studies describes methods for the analysis of Traditional Chinese Medicine (TCM). The studies will be covered in 2 blog posts, this one and the next.

Importance of Solvent Quality in UHPLC & HPLC Analysis

  
  
  
  
  
  
hplc solvent quality

I am pleased to present a recently released technical note on how to optimize and monitor the quality of your solvents when using UV-Vis absorption, fluorescence detection, or charged aerosol detection with HPLC or UHPLC.

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