Recently, an interesting study on the clinical development of monoclonal antibody-based drugs in HIV and HCV diseases (link to full, free article) crossed my desk that made for interesting reading as it discussed the advantages in using monoclonal antibodies (MAbs) in the treatment of infectious diseases, such as HIV and HCV, as more viruses become resistant to current drugs. The advantages of MAbs include low toxicity, highly specific interactions, good biological compatibility, and high versatility.

I am pleased to introduce our blog readers to Charlie Chromeleon, the face of our latest Chromatography Data System (CDS) software release! This is an exclusive interview with Charlie and you heard it first here!

I am pleased to present these fascinating research articles using high sensitivity electrochemical detection in the field of metabolomics (study of chemical fingerprints left by cellular processes).

In this blog post, we cover the analysis of carbohydrates, which are difficult to analyze because they have similar physical and chemical characteristics, and do not have a suitable chromophore for UV detection.

Metabolomics is the study of metabolites, which can be defined as any molecule less than 1 kDa in size. (Source and link Wikipedia). And, if you further read the same page, it says that gas chromatography (GC), high performance liquid chromatography (HPLC), and Capillary electrophoresis are the three separation methods used in the study of metabolites.

Here's an analysis that I am blogging about for the very first time: an automated and simplified method for headspace (HS) analysis of volatile organic compounds (VOCs) possibly present in food packaging materials! 

Recently, I tweeted a story on this study titled, Kinetic Model for the Formation of Acrylamide during the Finish-Frying of Commercial French Fries published in the ACS Journal of Agricultural and Food Chemistry. As per the study abstract, it studied the "fundamental chemical reaction pathways of the finish-frying" to be able to predict the acrylamide content of finished french fries. This would then assist in reducing the acrylamide content in the fries!

This post presents a new method using a monolith HPLC column (Thermo Scientific ProSwift ConA-1S Affinity column) released a couple of years ago for the fast, highly efficient enrichment and purification of Concanavalin (Con A) binding glycans, glycopeptides, and glycoproteins from complex samples.

The European has issued a series of regulations for marine biotoxins because toxic microalgal blooms in marine and fresh water have resulted in the deaths of wild animals and domestic livestock. In addition, several cases of poisoning in humans have been associated with the direct consumption of shellfish, fish, or water contaminated by algal toxins. Typically, humans suffer self-limiting symptoms, such as gastrointestinal disorders or allergic-like episodes but more severe symptoms of the neurological type can lead to death.

It has been some time since my last post.  There are some good reasons for that, I have been traveling on the North American Seminar Tour.  Look for posts on that later.  Let’s start things up again with some training.  There is one thing that we all must do on all GC-MS systems regardless of the instrument manufacturer, clean the source.  There are tricks that we all come up with to make this job faster and easier for ourselves.  I’m not sure all of the tricks make it easier but at least they seem that way.  So for the training on source removal we will go through the following steps;