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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Pharmaceutical USP 232 Chapter Revisions & Harmonization with ICH Q3D

  
  
  
  
  
  
trace element determination in APIs

As practitioners in the world of pharmaceutical manufacturing and quality control, you’ll know that the U.S. Pharmacopeial Convention (USP) 232 and its requirements for trace element determination in APIs, excipients and all other materials that make their way into, or are in contact with your finished products is on the horizon. The implementation date for meeting the demands of this regulation, as set by the U.S. Pharmacopeial Convention, and its companion protocol, USP 233, was, until last week, 1st December 2015, but on 14th January this year, the USP announced that this date was to be pushed back to 1st January 2018. The final specifics of USP 232 have yet to be agreed upon, with further changes having been recently (October 2014) proposed for elemental impurities, with the aim of aligning USP 232 with its European counterpart guidelines, as described in the publication, Guideline for Elemental Impurites Q3D, (downloadable PDF) and referred to as ICH Q3D. 

Arsenic Speciation in Rice: Fast & Simple Analysis Using IC-ICP-MS

  
  
  
  
  
  
inorganic arsenic speciation in rice

In my previous blog titled: Arsenic Speciation: The Media and the Science (link to blog post) I promised updates on this hot topic and as a big plus for me personally, this review incorporates my passion for ion analysis. My previous discussion points highlighted the importance of measuring the inorganic arsenic species, commenting on upcoming regulations and the ongoing research at the Institute for Global Food Security at Queens University Belfast (QUB) (link to website) and here I wanted to share the very latest analytical method on the subject published just last month.

Ready-To-Go Qualification Tools for Trace Metals in Pharma Analysis

  
  
  
  
  
  
compliance for USP 232 233

It’s appropriate I am writing this blogpost in December 2014; exactly one year away from the start of new regulation from U.S. Pharmacopeial Convention (USP) that mandates the testing of fifteen trace elements (metals) in pharmaceutical products from 1st December 2015 onwards as per USP <232> & <233> (link to USP site on these regulations).

So, the clock is now ticking towards this date and I’m meeting nutraceutical, pharmaceutical, and biopharmaceutical manufacturers across the globe that are making preparations to meet these new pharmaceutical regulations.

Overcoming Interference Challenges During Trace Elemental Analysis

  
  
  
  
  
  
trace elemental interference in ICP-OES, ICP-MS, ICP-MS analysis

Applications for trace elemental analysis are quite common, ranging from toxic metal analysis in water, lead analysis in toys, to trace metals analysis for semiconductor, with detection level requirements ranging from parts per million (ppm) to sub parts per trillion (ppt). The trace contamination of certain elements can lead to severe health problems or cause defect in products.

ICP-MS Arsenic Speciation in Rice: The Media and The Science

  
  
  
  
  
  
quantification of inorganic arsenic in rice

Recently I watched a very thought provoking documentary by Dispatches on Channel 4 here in the UK which was all about arsenic in rice and rice products (link to U.S. FDA page). As I have a keen interest in ion analysis, I was intrigued to see if the science is consistent with the media story, so took on some research of my own.

Chromatography and Sample Preparation Terminology Guide

  
  
  
  
  
  
chromatography terminology

In this very short blog post, I wanted to provide a link to a great resource, Advanstar Science's Chromatography and Sample Preparation Terminology Guide (link to page where you can click Register, fill out a brief form and then download the guide).

Ion Chromatography Improves Chromium Speciation in Drinking Water

  
  
  
  
  
  
chromium in drinking water infographic

Did you know that new laws for measuring chromium in water are on the horizon and, in particular, hexavalent chromium (Cr6+) is under evaluation for new legislation by the U.S. EPA (link to US EPA page on recommendations for Cr6+ monitoring) and the European EFSA (link to EFSA Scientific Opinion page on Cr6+). 

Ion Chromatography Improves Analysis of Lithium Ion Batteries!

  
  
  
  
  
  
analysis of lithium ion battery electrolytes

It does seem I have fuel cells on my mind but when I found that I had not written about a really well received webinar on the use of multiple chromatography techniques for the analysis of lithium ion batteries, I had to feature it before I forgot again! The webinar is now on-demand so you can play it at your leisure once you fill out a quick registration form. Click the image on the right or the title of the webinar below to access the webinar.

Chromatography Monitoring as per U.S. EPA UCMR 3: Two Webinars

  
  
  
  
  
  
UCMR 3 inorganic and organic contaminant analysis

The two-parts of this upcoming webinar series presented in this post cover multiple chromatography techniques (gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry, ion chromatography, and Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry) for the monitoring of inorganic and organic contaminants as per the U.S. EPA's Unregulated Contaminant Monitoring Rule 3 (UCMR 3) (link to U.S. EPA page). Both webinars will feature a customer case study from Eurofins Eaton Analytical Inc.; Dr. Andy Eaton, Vice President and Technical Director at Eurofins Inc. will be in a discussion with Dr. Richard F. Jack, our NA Environmental Market Manager at Thermo Fisher Scientific Inc.

Chromatography Solution Online Center Now Open!

  
  
  
  
  
  
liquid chromatography, ion chromatography, gas chromatography, and chromatography software

Do you know about our collaboration with Chromatographyonline.com in presenting an online Chromatography Solution Center to serve as a resource for chemists, scientists, and researchers by presenting the latest developments and applications, in chromatography?

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