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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Wine Testing: Arsenic, Analysis and a Classic Movie

arsenic analysis in wine

“For a gallon of elderberry wine, I take a teaspoon full of arsenic then add half a teaspoon of strychnine and then just a pinch of cyanide,” says one of the adorable maiden aunts in the classic movie Arsenic and Old Lace (link to brilliant youtube clip) starring Cary Grant. You could be forgiven for thinking the recent news stories on trace element arsenic in wine came straight from this 1940s dark comedy but unfortunately it did not; this is an extremely serious food safety testing matter that has resulted in a lawsuit being filed.

Will Strontium Get on the Final Contaminant List for Drinking Water?

strontium contamination in drinking water

Talking about drinking water regulations, you may have heard that the U.S. EPA made a preliminary determination for a strontium regulation in drinking water (link to the announcement) on October 20, 2014. The EPA planned to collect comments on the preliminary determination by December 19, 2014 and by the end of 2015, the EPA will have made the final decision if strontium, as a metal analysis component, will get on the primary drinking water contaminant list (link to EPA drinking water page). Once the final approval is made, within 24 months, the EPA will come up with the maximum contaminant level goal (MCLG) for strontium in drinking water and within another 18 months, the EPA will finalize the regulation.

Elemental Speciation for Environmental Testing: Spotting the Bad

chromium and arsenic speciation using IC-ICP-MS

After my last two posts on dealing with the challenges of interference in trace elemental analysis (link to post) and an overview on the analysis of fracking wastewater (link to post), I thought I would turn my attention to discussing elemental speciation in this post.

Heavy Metals in Food: ICP Analysis or Time for a Detox?

heavy metal analysis in food

As my friend has just finished his January health detox diet (link to webmd site) apparently feeling much the better for it and I was wondering about the real science behind it. During some simple web searching I became distracted by some fascinating products for performing a heavy metals detox and I will be honest I had never heard of this; but, having a keen interest in trace metal analysis I dug deeper.

Pharmaceutical USP 232 Chapter Revisions & Harmonization with ICH Q3D

trace element determination in APIs

As practitioners in the world of pharmaceutical manufacturing and quality control, you’ll know that the U.S. Pharmacopeial Convention (USP) 232 and its requirements for trace element determination in APIs, excipients and all other materials that make their way into, or are in contact with your finished products is on the horizon. The implementation date for meeting the demands of this regulation, as set by the U.S. Pharmacopeial Convention, and its companion protocol, USP 233, was, until last week, 1st December 2015, but on 14th January this year, the USP announced that this date was to be pushed back to 1st January 2018. The final specifics of USP 232 have yet to be agreed upon, with further changes having been recently (October 2014) proposed for elemental impurities, with the aim of aligning USP 232 with its European counterpart guidelines, as described in the publication, Guideline for Elemental Impurites Q3D, (downloadable PDF) and referred to as ICH Q3D. 

Arsenic Speciation in Rice: Fast & Simple Analysis Using IC-ICP-MS

inorganic arsenic speciation in rice

In my previous blog titled: Arsenic Speciation: The Media and the Science (link to blog post) I promised updates on this hot topic and as a big plus for me personally, this review incorporates my passion for ion analysis. My previous discussion points highlighted the importance of measuring the inorganic arsenic species, commenting on upcoming regulations and the ongoing research at the Institute for Global Food Security at Queens University Belfast (QUB) (link to website) and here I wanted to share the very latest analytical method on the subject published just last month.

Ready-To-Go Qualification Tools for Trace Metals in Pharma Analysis

compliance for USP 232 233

It’s appropriate I am writing this blogpost in December 2014; exactly one year away from the start of new regulation from U.S. Pharmacopeial Convention (USP) that mandates the testing of fifteen trace elements (metals) in pharmaceutical products from 1st December 2015 onwards as per USP <232> & <233> (link to USP site on these regulations).

So, the clock is now ticking towards this date and I’m meeting nutraceutical, pharmaceutical, and biopharmaceutical manufacturers across the globe that are making preparations to meet these new pharmaceutical regulations.

Overcoming Interference Challenges During Trace Elemental Analysis

trace elemental interference in ICP-OES, ICP-MS, ICP-MS analysis

Applications for trace elemental analysis are quite common, ranging from toxic metal analysis in water, lead analysis in toys, to trace metals analysis for semiconductor, with detection level requirements ranging from parts per million (ppm) to sub parts per trillion (ppt). The trace contamination of certain elements can lead to severe health problems or cause defect in products.

ICP-MS Arsenic Speciation in Rice: The Media and The Science

quantification of inorganic arsenic in rice

Recently I watched a very thought provoking documentary by Dispatches on Channel 4 here in the UK which was all about arsenic in rice and rice products (link to U.S. FDA page). As I have a keen interest in ion analysis, I was intrigued to see if the science is consistent with the media story, so took on some research of my own.

Chromatography and Sample Preparation Terminology Guide

chromatography terminology

In this very short blog post, I wanted to provide a link to a great resource, Advanstar Science's Chromatography and Sample Preparation Terminology Guide (link to page where you can click Register, fill out a brief form and then download the guide).

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