blog masthead 828x138

 

 

 

 

A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

Subscribe via E-mail

Your email:

Our Twitter Feed...

Follow Me

Browse by Tag

Current Articles | RSS Feed RSS Feed

A Milestone in Pesticides Analysis for Orbital Trap Mass Spectrometry

  
  
  
  
  
  

Australia Recalls Tonic Water – The Hazards of Food Mislabeling

  
  
  
  
  
  
analysis of quinine in tonic water

Earlier this month I read that Australia has recalled Indian Tonic Water (link to story) as some of the tonic water bottles were mislabeled as soda water and, hence, the labels did not include information on presence of quinine in the beverages; both Australia and the EU require that the presence of quinine in such beverages be declared. Indeed, the UK's SCHEDULE 8: MISLEADING DESCRIPTIONS states that "The name “Indian tonic water” or “quinine tonic water” shall not be applied to any drink unless the drink contains not less than 57 mg of quinine (calculated as quinine sulphate B.P.) per litre of the drink.

Sample Preparation: Three Techniques Reviewed

  
  
  
  
  
  
hplc sample preparation

I hope you found the last installment on Hydrophobic Interaction Liquid Chromatography (link to blog post) useful. Supporting my goal to discuss and provide resources on the latest tools and techniques that will help improve and speed up your day-to-day work in the lab, I will discuss sample preparation for HPLC in this post.

Troubleshooting Pharmaceutical Assays in HPLC & UHPLC

  
  
  
  
  
  
troubleshooting pharmaceutical HPLC and UHPLC applications

The focus of this post to present several resources for troubleshooting UHPLC and HPLC methods in pharmaceutical and biopharmaceutical applications. How this post came about was with my receiving the first resource via an email and then learning about the webinar.

Glycan Analysis with a Particular Focus on the Immune System

  
  
  
  
  
  
Human Immune System attack a virus

As an immunologist and analytical scientist, I have always been fascinated with the immune system and how pathogens and the immune system have evolved hand-in-hand as the former seeks new ways to avoid and disguise itself from the latter and the immune system develops alternative mechanisms to seek out and destroy invading pathogens. It’s a miniature arms race occurring inside each and every one of us, but only really becoming noticeable to us when we feel the effects of the raging battle through illness. I do believe that the immune system represents a model and spell-binding system in which to view evolution occurring, although my young children would probably disagree and much prefer an alternative bedtime story to one of my favorite books for children, titled, Your Amazing Immune System! (details of how to get a free copy of this book if you wish to go with the immunological children’s bedtime story.)

Is Your Wine Authentic: An Ion Chromatography Method

  
  
  
  
  
  
authenticating wine

On the agenda of the recent UK Laboratory of the Government Chemist (LGC) meeting I attended was a fascinating talk titled: Wine Fraud – Catching the Cheats (link to downloadable pdf of the talk) by renowned wine expert Geoff Taylor (link to profile) of Campden BRI. Although Geoff’s does not discuss Ion Chromatography (IC), his abstract has some startling facts where fraud could potentially make serious money for the criminals, ranging from the fine wine market where volume is low and unit prices are high through to the mass volume market.

HPLC Conference Overload & Fractal Chromatography Columns

  
  
  
  
  
  
hplc protein peptide analysis

I occasionally get conference overload, and this was the case a few months ago with three chromatography conferences in two weeks (HPLC 2014, ISCC at Riva, and the UK ChromSoc AGM), two oral presentations and five posters to present plus the many seminars given by other delegates to listen to as well. It sounds busy and it is intensive as most of the hard work comes from the interactions outside of the lecture halls.

Fast Pharma Drug (Nevirapine) Impurity Profiling Using UHPLC-DAD

  
  
  
  
  
  
Pharma Drug Nevirapine Impurity Profiling

It has been a long while, almost two months, since I wrote about pharmaceutical drug analysis on this blog in post, titled, Charged Aerosol Detection Speeds Analysis of Pharma Drug Impurities (link to post), and I found the UHPLC application featured here while looking for something else on our website. I am pleased to write about this application because it features our latest UHPLC system (Thermo Scientific Vanquish UHPLC system) and can be used with our method transfer tool to speed and streamline the process of adapting HPLC parameters for UHPLC analysis.

Charged Aerosol Detection Speeds Analysis of Botanicals

  
  
  
  
  
  
tcm analysis

Previously, this blog featured liquid chromatography analysis of Traditional Chinese Medicine (TCM) in a blog post that presented a HPLC applications notebook (link to blog post) on the subject; here, I discuss an HPLC application for the analysis of botanicals and natural products.

Pomegranate Juice Fraud: HPLC Detects What's in Your Juice!

  
  
  
  
  
  
Pomegranate Juice adulteration testing

Did you know that a peer-reviewed study, titled, International multidimensional authenticity specification (IMAS) algorithm for detection of commercial pomegranate juice adulteration, (link to study), published in the J Agric Food Chem journal, found that only 35% of the commercially available pomegranate juice qualifies as authentic pomegranate juice?

All Posts