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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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HPLC Determination of Growth Stimulants in Farm Animals

fast HPLC analysis of clenbuterol, ractopamine, and phenolethanolamine in meat

This blog post features the efficient and sensitive HPLC analysis of the synthetic compounds clenbuterol, ractopamine, and phenolethanolamine which have been extensively used as growth stimulants in farm animals (and by athletes seeking enhanced performance). The reason for concern is that these compounds, grouped as e β2-agonists, may remain as residues in meat intended for human consumption. While food safety concern for the presence of ractopamine is low, high levels of clenbuterol can cause severely increased heart rate and blood pressure, anxiety, palpitation, and skeletal muscle tremors. (Source & link: Centre for Food Safety in HongKong.) Clenbuterol has been banned by many countries including the USA, European Union, and China; and, the newly introduced phenolethanolamine is already banned in China.

Importance of Solvent Quality in UHPLC & HPLC Analysis

hplc solvent quality

I am pleased to present a recently released technical note on how to optimize and monitor the quality of your solvents when using UV-Vis absorption, fluorescence detection, or charged aerosol detection with HPLC or UHPLC.

Accelerated Solvent Extraction & UHPLC Analysis of Mangosteens

HPLC analysis of xanthones

The fascinating UHPLC study in this blog post was presented at the recent Pittcon conference and presents a fast extraction method using Accelerated Solvent Extraction (ASE) which requires only 30 mins and provides >96% recovery with excellent reproducibility!

HPLC Drug Analysis Columns Proposed in USP New & Revised Monographs

hplc columns for drug analysis

I know this post might come across as a bit of a puff piece (promotional piece) but when I received the two emails announcing the various HPLC columns that have been proposed for use in United States Pharmacopeia’s (USP) Pharmacopeia Forum (link to site) monographs for the analysis of pharmaceuticals, I was a bit thrilled and wanted to share the good news with our blog readers.

UHPLC and HPLC Methods for Improved Analysis of Peptides

peptide analysis by HPLC

The interesting poster presented in this blog post was presented at the recent Pittcon conference and it describes the development of UHPLC and HPLC electrochemical detection (EC) methods for the measurement of different cystine-containing peptides including simple peptides (glutathione), medium-sized peptides (insulin), cyclic peptides (oxytocin and vasopressin) and peptides with cystine knots (cyclotides). (Image accompanying this post is of an insulin molecule.)

Chromatography Vial Identification System Launched!

chromatography vial labeling

I am pleased to feature our recently released chromatography vial labeling and identification system (Thermo Scientific Virtuoso Vial Identification System) designed to eliminate costly labeling errors and boost productivity!

Speeding Universal Method Transfer from HPLC to UHPLC!

hplc method transfer to uhplc

Can you easily and quickly apply all rules for a successful HPLC-to-UHPLC method transfer? If you are doing this frequently, you are probably doing the math on a piece of paper each time and wasting valuable time; here, we are pleased to present a tool plus a technical note that could help speed things up significantly for chromatographers!

Top 10 Features of a Successful Chromatography Data System!

chromatography  software

I am pleased to share a useful webinar focused on what should be the requirements of a successful chromatography software plus some resources that could help speed up your work.

HPLC Research Studies in Plant Cell Biology & Botany (II)

hplc analysis of plant biology

This post is the second part on the use of the HPLC technique in plant cell physiology studies; the first set of research studies are blogged in the post titled, HPLC Research Studies in Plant Cell Biology & Botany (I) (link to post). 

HPLC Enhancements for Fast Biopharma Analysis: On-Demand Webinar

charge variant and glycan analysis

The on-demand webinar (under 60 mins) featured in this post was recently posted on our website and you can view it without filling out a registration form! The webinar presents our new Bio-UHPLC platform (Thermo Scientific Dionex UltiMate 3000 BioRS system) and consumables for charge variant and glycan analysis.

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