blog masthead 828x138

 

 

 

 

A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

Subscribe via E-mail

Your email:

Our Twitter Feed...

Follow Me

Browse by Tag

Current Articles | RSS Feed RSS Feed

HPLC Solution Kit for Simultaneous Analysis of Pharma Counterions

  
  
  
  
  
  
hplc counterion analysis

I am pleased to present our recently released HPLC counterion solution kit for pharmaceutical QA/QC (Thermo Scientific IonCount solution) which simplifies the analysis and setup of complete HPLC workflows for common and less common organic and inorganic counterions in pharmaceutical analysis. Those working in this field know that obtaining qualitative and quantitative information of pharmaceutical drugs and residual salts is critical for determining the purity, mass balance and stoichiometry of drug formulations and this solution can speed up the screening and assaying of a broad variety of counterions and active pharmaceutical ingredients (APIs).

Chromatography and Sample Preparation Terminology Guide

  
  
  
  
  
  
chromatography terminology

In this very short blog post, I wanted to provide a link to a great resource, Advanstar Science's Chromatography and Sample Preparation Terminology Guide (link to page where you can click Register, fill out a brief form and then download the guide).

HPLC Method for Metabolite Profiling of Wine, Juice, & Tea

  
  
  
  
  
  
metabolite profiling of tea wine fruit juice

I am pleased to present a recently released application note featuring a gradient HPLC method to study product authenticity, such as differentiating wine varietals, orange juice varietals and growing region, and distinguishing tea blends, and identifying adulteration in juices, such the blending of orange juice with cheaper juices or the inclusion of peel or pulp wash.

HPLC & CAD: Surfactants and Emulsifiers Applications Notebook

  
  
  
  
  
  
analysis of emulsifiers and surfactants using hplc

Did you know that the global food emulsifiers market is one of the fastest growing markets in the food ingredient market and is estimated to grow to $2,858.6 million by 2018? (Link to market research website.) Emulsifiers are used to stabilize emulsions in the food industry plus used as an additive to reduce fat content. Surfactants are compounds that lower the surface tension between liquids or a liquid and a solid, and are used as detergents, wetting agents, emulsifiers, foaming agents, and dispersants. (Definition and link Wikipedia page.) Other important uses of surfactants include industrial applications in lubrication, textile processing, petroleum recovery, and wastewater treatment.

HPLC Applications Notebook: Traditional Chinese Medicine

  
  
  
  
  
  
Traditional Chinese Medicine HPLC analysis

Did you know that the oldest work on Traditional Chinese Medicine (TCM) appeared in 200 B.C. and that the first TCMs and acupuncture needles appeared around 2500 BCE in China? (Link to site.) And, here I am pleased to present to you our recently released notebook featuring HPLC applications for TCM to help ensure the efficacy, purity and safety of these traditional remedies!

Electrochemical Detection Troubleshooting

  
  
  
  
  
  
troubleshooting Electrochemical Detection (ECD)

I came across two technical notes on troubleshooting Electrochemical Detection (ECD) problems, featured in this blog post, while reading up on a recently released HPLC application that used this type of detection. And, soon after, I found a poster note on the topic and thought this would make for a useful read for those working in HPLC-ECD applications. For those new to this type of detection, ED is the most sensitive and selective mode of LC detection for the measurement of oxidizable or reducible compounds.

Scaling Down Sample Extraction for Limited & Volatile Sample Volumes

  
  
  
  
  
  
bioanalysis sample preparation

In an earlier post on the use of our recently released solid-phase extraction (SPE) micro elution plates (Thermo Scientific SOLA┬Á Solid Phase Extraction [SPE] Well Plates) for bioanalysis, I covered how these well plates can enhance sample concentration by 20X (link to post), and here I am pleased to present an application note on how these plates can be used to facilitate the scale down of an extraction method for use when sample volume is limited or volatile as in the case of bioanalytical samples.

Chromatography Analysis of Additives & More in Beverages (II)

  
  
  
  
  
  
analysis of additives in beverage

After last month's post featuring chromatography applications for the analysis of sugars and artificial sweeteners in beverages (link to post), I am pleased to present two more application notebooks for the analysis of beverages, one for the analysis of carbonated beverages and the other for the analysis of additives in beverages.

Creating An HPLC Affinity Titer Column for Monoclonal Antibody Analysis

  
  
  
  
  
  
monoclonal antibody analysis

In the poster presented in this blog post, scientists from our Sunnyvale (USA) research lab describe a straightforward method for creating designer assays for QC analysis of monoclonal antibodies (mAb) using our HPLC-compatible, streptavidin-coated monolith column. This affinity column produces narrow concentrated peaks with minimal diffusion, allows for titer analysis over a wide concentration range, and is applicable for a range of applications from small-scale protein to antibody titer analysis.

Chromatography Analysis of Sugars & Sweeteners in Beverages (I)

  
  
  
  
  
  
chromatography sugars in beverages

Have you been following the increasing efforts by various governments to regulate the amount of sugar in beverages or impose sugar taxes on sugary drinks in an effort to reduce sugar in food and beverage products? In one story, UK's chief medical officer told a committee of MPs that a sugar tax may have to be introduced to curb obesity rates (link to story) and in another story, the state of Illinois, in the USA, is considering a new tax on sugary beverages (link to story). By the way, a new study concluded that fruit juice has only a bit less fructose than sugary sodas (link to study).

All Posts