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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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HPLC Drug Analysis Columns Proposed in USP New & Revised Monographs

  
  
  
  
  
  
hplc columns for drug analysis

I know this post might come across as a bit of a puff piece (promotional piece) but when I received the two emails announcing the various HPLC columns that have been proposed for use in United States Pharmacopeia’s (USP) Pharmacopeia Forum (link to site) monographs for the analysis of pharmaceuticals, I was a bit thrilled and wanted to share the good news with our blog readers.

UHPLC and HPLC Methods for Improved Analysis of Peptides

  
  
  
  
  
  
peptide analysis by HPLC

The interesting poster presented in this blog post was presented at the recent Pittcon conference and it describes the development of UHPLC and HPLC electrochemical detection (EC) methods for the measurement of different cystine-containing peptides including simple peptides (glutathione), medium-sized peptides (insulin), cyclic peptides (oxytocin and vasopressin) and peptides with cystine knots (cyclotides). (Image accompanying this post is of an insulin molecule.)

Chromatography Vial Identification System Launched!

  
  
  
  
  
  
chromatography vial labeling

I am pleased to feature our recently released chromatography vial labeling and identification system (Thermo Scientific Virtuoso Vial Identification System) designed to eliminate costly labeling errors and boost productivity!

Speeding Universal Method Transfer from HPLC to UHPLC!

  
  
  
  
  
  
hplc method transfer to uhplc

Can you easily and quickly apply all rules for a successful HPLC-to-UHPLC method transfer? If you are doing this frequently, you are probably doing the math on a piece of paper each time and wasting valuable time; here, we are pleased to present a tool plus a technical note that could help speed things up significantly for chromatographers!

Top 10 Features of a Successful Chromatography Data System!

  
  
  
  
  
  
chromatography  software

I am pleased to share a useful webinar focused on what should be the requirements of a successful chromatography software plus some resources that could help speed up your work.

HPLC Research Studies in Plant Cell Biology & Botany (II)

  
  
  
  
  
  
hplc analysis of plant biology

This post is the second part on the use of the HPLC technique in plant cell physiology studies; the first set of research studies are blogged in the post titled, HPLC Research Studies in Plant Cell Biology & Botany (I) (link to post). 

HPLC Enhancements for Fast Biopharma Analysis: On-Demand Webinar

  
  
  
  
  
  
charge variant and glycan analysis

The on-demand webinar (under 60 mins) featured in this post was recently posted on our website and you can view it without filling out a registration form! The webinar presents our new Bio-UHPLC platform (Thermo Scientific Dionex UltiMate 3000 BioRS system) and consumables for charge variant and glycan analysis.

HPLC & Charged Aerosol Detection: Fast Analysis of Vaccine Adjuvants

  
  
  
  
  
  
analysis of vaccine adjuvants

I am pleased to feature a recently released, fast and sensitive HPLC method for the measurement of the strength and purity of vaccine adjuvant formulations. A vaccine adjuvant (Wikipedia) is any substance that helps promote the effectiveness of a vaccine by reducing the amount or frequency of the required dose, by prolonging the duration of immunological memory, or by modulating the involvement of humoral or cellular responses. Many adjuvants under investigation contain components that are not readily analyzed by traditional HPLC with UV detection, including triterpenoid glycosides, sterols, fatty acids, and phospholipids that lack suitable UV chromophores.

LC-MS Analysis of Degradation Products of V Nerve Agents!

  
  
  
  
  
  
trace analysis of nerve gas degradation products

We have very small toxicology and forensic application sections on this blog but ever since I wrote about the use of our LC-MS systems in a UK study on suspected chemical warfare used by the Russian Special Forces during the course of the Moscow Theater Siege in 2002 (link to post), I have been fascinated by the subject. Hence, when I recently received notification about another similar study, again using one of our LC-MS solutions, for the study of degradation products of nerve agents, it was on the top of my list to write about.

Chromatography Monitoring as per U.S. EPA UCMR 3: Two Webinars

  
  
  
  
  
  
UCMR 3 inorganic and organic contaminant analysis

The two-parts of this upcoming webinar series presented in this post cover multiple chromatography techniques (gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry, ion chromatography, and Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry) for the monitoring of inorganic and organic contaminants as per the U.S. EPA's Unregulated Contaminant Monitoring Rule 3 (UCMR 3) (link to U.S. EPA page). Both webinars will feature a customer case study from Eurofins Eaton Analytical Inc.; Dr. Andy Eaton, Vice President and Technical Director at Eurofins Inc. will be in a discussion with Dr. Richard F. Jack, our NA Environmental Market Manager at Thermo Fisher Scientific Inc.

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