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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Authenticity of Dietary Supplements in Question: A Recall in New York- Part 2

  
  
  
  
  
  
dietary supplement recall

On Feb 5, 2015 I wrote a blog post, titled, Authenticity of Dietary Supplements in Question: A Recall in New York, (link to blog post). Now, I have a part 2 of this story, in that the State Attorney Generals from the States of Connecticut, Indiana and Puerto Rico along with New York have formed a coalition to expand the herbal supplement industry investigation (link to story).

To Vaccinate or Not to Vaccinate? But, What About Cancer Vaccines?

  
  
  
  
  
  
Measles Cell

As a former drug-formulation chemist, I have been following the debate and discussion around the recent outbreak of measles in the U.S. among unvaccinated individuals with deep interest because I wonder if this turning away from vaccines could also mean that such individuals may turn away from other vaccines, such as those for preventing cancer. It is commonly understood that it is better to prevent disease (Centers for Disease Control and Prevention web link) than to treat it after it has occurred. (By the way, the stunning image is of a measles cell.)

Guiding the Sweet Revolution in Glycomics

  
  
  
  
  
  
HPAE-PAD mass spectrometry analysis of glycoproteins

There’s been a lot of interest recently in the study of glycans and glycoforms, such as proteins and peptides that have glycans attached to them. The analysis of glycans (also known as carbohydrates, or sometimes simply sugars) is of growing importance to sciences as diverse as pharmaceutical drug development, cancer research, stem cell research and biofuels development.

How Are You Controlling Copper Additive Performance in Electroplating Baths?

  
  
  
  
  
  
semiconductor chips

Getting fast, accurate measurements on the performance of additives used in semiconductor electroplating baths is of critical importance in providing plating quality which includes uniformity, brightness, and consistency. Liquid chromatography with charged aerosol detection (CAD) and electrochemical detector techniques ensures reliable plating by detecting individual components, their byproducts, and other components in process monitoring applications. The technique has been successfully applied to the determination of individual organic additives in acid copper and nickel plating baths.

Why I Turned from Phosphorylation to Glycan Analysis

  
  
  
  
  
  
glycosylation analysis by UHPLC

Most of my early research career focused on the post-translational modifications (PTMs) of proteins and in those days there was only one worthy PTM in my eyes and that was phosphorylation while glycosylation hardly registered. That was because phosphorylation governed important cellular processes (in my view at least) such as cell signalling; however, my love of phosphorylation slowly waned as I grew to understand the only reliable method to measure phosphorylation was with the potentially harmful radioactive Phosphorus-32 (32P)! (Link to Wikipedia page.) That’s when I started to get more interested in glycosylation and the huge diversity of modifications this could entail, after all phosphorylation was only adding phosphate on to a serine, threonine or tyrosine. Glycosylation offered more possibilities and intrigue and the opportunity to use other analytical techniques that didn’t involve 32P.

Give Your Valentine: Antioxidants!

  
  
  
  
  
  
analysis of polyphenols in wine

Of all the special days on the calendar, I think Valentine’s Day has to be the healthiest. Think about it. Christmas has all those fattening cookies, fruitcake, and candy canes – not to mention the stress of shopping, wrapping, and paying off the credit cards. Thanksgiving is known for overeating and has pies, pies, pies. Halloween? Please. The Fourth of July is grilled meat (HCAs and PAHs anyone?) and ice cream. But Valentine’s Day is red wine, chocolate, and flowers.

Authenticity of Dietary Supplements in Question: A Recall in New York

  
  
  
  
  
  
dietary supplement authentication by HPLC

The authenticity and efficacy of dietary supplements (DS) have been a concern for many years now. And, on Tuesday, February 3, the New York State Attorney General’s Office announced a state-wide recall of herbal supplements sold through multiple major retailers (link to story). The recall is a result of a study conducted by authorities that found that many of these products were fraudulent and potentially dangerous. Supplements called into question include products said to contain Ginkgo Biloba and St. John’s wort, amongst others.

A Milestone in Pesticides Analysis for Orbital Trap Mass Spectrometry

  
  
  
  
  
  

Australia Recalls Tonic Water – The Hazards of Food Mislabeling

  
  
  
  
  
  
analysis of quinine in tonic water

Earlier this month I read that Australia has recalled Indian Tonic Water (link to story) as some of the tonic water bottles were mislabeled as soda water and, hence, the labels did not include information on presence of quinine in the beverages; both Australia and the EU require that the presence of quinine in such beverages be declared. Indeed, the UK's SCHEDULE 8: MISLEADING DESCRIPTIONS states that "The name “Indian tonic water” or “quinine tonic water” shall not be applied to any drink unless the drink contains not less than 57 mg of quinine (calculated as quinine sulphate B.P.) per litre of the drink.

Sample Preparation: Three Techniques Reviewed

  
  
  
  
  
  
hplc sample preparation

I hope you found the last installment on Hydrophobic Interaction Liquid Chromatography (link to blog post) useful. Supporting my goal to discuss and provide resources on the latest tools and techniques that will help improve and speed up your day-to-day work in the lab, I will discuss sample preparation for HPLC in this post.

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