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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Chromatography Analysis of Additives & More in Beverages (II)

analysis of additives in beverage

After last month's post featuring chromatography applications for the analysis of sugars and artificial sweeteners in beverages (link to post), I am pleased to present two more application notebooks for the analysis of beverages, one for the analysis of carbonated beverages and the other for the analysis of additives in beverages.

Creating An HPLC Affinity Titer Column for Monoclonal Antibody Analysis

monoclonal antibody analysis

In the poster presented in this blog post, scientists from our Sunnyvale (USA) research lab describe a straightforward method for creating designer assays for QC analysis of monoclonal antibodies (mAb) using our HPLC-compatible, streptavidin-coated monolith column. This affinity column produces narrow concentrated peaks with minimal diffusion, allows for titer analysis over a wide concentration range, and is applicable for a range of applications from small-scale protein to antibody titer analysis.

Chromatography Analysis of Sugars & Sweeteners in Beverages (I)

chromatography sugars in beverages

Have you been following the increasing efforts by various governments to regulate the amount of sugar in beverages or impose sugar taxes on sugary drinks in an effort to reduce sugar in food and beverage products? In one story, UK's chief medical officer told a committee of MPs that a sugar tax may have to be introduced to curb obesity rates (link to story) and in another story, the state of Illinois, in the USA, is considering a new tax on sugary beverages (link to story). By the way, a new study concluded that fruit juice has only a bit less fructose than sugary sodas (link to study).

HPLC Solid-Core Columns For Fast Pharma Analysis (II)

HPLC analysis of Analgesic Compounds

In Part II on our solid-core HPLC columns, I am pleased to feature two application notes featuring the use of these columns in pharma and biopharma development. (Part I, HPLC Solid-Core Columns For Fast Pharma Analysis (I), featured a technical article, a technical note, and an on-demand webinar.)

Sample Preparation for Analytes Susceptible to Degradation or Loss

bioanlysis sample preparation

Here is the third application note in this series on improving sample preparation for bioanalytical and clinical research applications using our recently released solid-phase extraction (SPE) micro elution plates (Thermo Scientific SOLA┬Á Solid Phase Extraction [SPE] Well Plates). The previous two application notes are presented in the following blog posts:

Chromatography Solutions for Analysis of Milk

hplc milk analysis
How this blog post on the chromatography analysis of milk and milk products came about was the featuring of the following two fascinating stories on our twitter stream and our Chromatography Solutions Facebook page on the topic:
  • Did you know that before refrigeration, people in Russia and Finland dropped live brown frogs into milk to keep it fresh? Moscow State University researchers discovered the science behind this odd custom; they found that amphibians' skin secretions are filled with peptides, which are antimicrobial compounds that are as effective against Salmonella and Staphylococcus bacteria as prescription antibiotics. 
  • The ability of geographically diverse Africans to digest milk has been linked to spread of cattle raising. Researchers found that the ability to digest milk became a selective force in the populations that raised cattle and consumed fresh cow, camel, or goat milk and identified three additional genetic variants with lactase persistence that had not been identified previously. By the way, it was the largest ever study of its kind in Africa.

In our 90-plus page Beverages Applications Notebook: Milk (downloadable PDF), we present applications for monitoring the compositional quality and safety of milk and milk products such as baby formula, lactose-free milk products, and milk for tracking contamination, adulteration, product consistency, and to ensure regulatory compliance.

HPLC Solid-Core Columns For Fast Pharma Analysis (I)

hplc pharma analysis columns

A two-part series on several resources for our solid-core HPLC columns has been on my to-do list for a while now and kept getting pushed back down the list every week until I decided that I simply had to write about them. So, here goes.

LC-MS Platform for the Analysis of Finished Petroleum Products (II)

chemical characterization of petroleum

In Part II of this series on chromatography solutions for the analysis of oil and gas refinery products, I am pleased to present a robust LC-MS method for the complete analysis of finished petroleum products. (Part I is featured here: Ion Chromatography Speeds Petroleum Refinery Analysis (I).)

Monoclonal Antibody Characterization: Technical Guide on Columns

hplc Monoclonal Antibody Characterization

I am pleased to present here our recently released Biomolecules Technical Guide (downloadable PDF) on the HPLC column best suited to Monoclonal Antibody (mAb) characterization. If you work in this field, you will be aware that mAb treatment is one of the most effective methods of diagnosis and treatment of a broad range of diseases, including autoimmune disorders, cardiovascular diseases, infectious diseases, cancer, and inflammation. And, since there is an extensive development pipeline for protein and mAb therapeutics, there is a need for innovative and efficient analytic tools.

LC-MS Solutions for Analysis of Marine Biotoxins in Shellfish

hplc analysis of marine biotoxins in shellfish

Did you know that marine biotoxins resulting from algal blooms can accumulate in bivalve mollusks as these organisms filter large quantities of water and can poison human beings who consume the mollusks? For example, in the State of New York (USA), one can check the sanitary conditions of shellfish lands and find out if they are closed for shellfish collection (link to site). Studies have shown that phosphorus in agricultural fertilizer is the primary cause of toxic algal blooms, as in the Great Lakes in the USA (link to article).

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