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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Chromatography Data System: Five Webinars to Speed up your Analysis!

  
  
  
  
  
  
chromatography software

I am pleased to present a series of five upcoming webinars on features in our using our award-winning chromatography data system (CDS) software (Thermo Scientific Dionex Chromeleon CDS software)! The goal of the webinars is to present the CDS software features that permit chromatographers to get the analysis right first time!

Chromatography Solution Online Center Now Open!

  
  
  
  
  
  
liquid chromatography, ion chromatography, gas chromatography, and chromatography software

Do you know about our collaboration with Chromatographyonline.com in presenting an online Chromatography Solution Center to serve as a resource for chemists, scientists, and researchers by presenting the latest developments and applications, in chromatography?

UHPLC Methods for Fast Screening in Early Drug Discovery!

  
  
  
  
  
  
HPLC, UHPLC, HILIC, charged aerosol detection

We recently presented a very well-attended webinar on HPLC and UHPLC methodologies for versatile and powerful new pharma solutions featuring the use of our hydophilic interacton liquid chromatography (HILIC) and other reverse phase columns and our latest charged aerosol detector (Thermo Scientific Dionex Corona Veo Charged Aerosol Detector). I also found several excellent resources (an applications guides and two poster notes) to supplement the the information in the webinar and thought it would be useful reading for those working in the field of early drug discovery.

LC-MS/MS Study of Metabolomic Changes in Nematode C. elegans

  
  
  
  
  
  
metabolomic analysis

I found the HPLC and mass spectrometry metabolomics application blogged here fascinating as I had just read about the destructive impact of nematodes on food crops (link to story), and after receiving the application note, I was compelled to do some research on the Internet on the particular nematode studied in the application, namely Caenorhabditis elegans. (Isn't the image accompanying this post beautiful?)

Sample Preparation Simplified with New Syringe Filter Membranes

  
  
  
  
  
  
chromatography syringe filters

This is a very short blog post as I wanted to share the news on some new chromatography syringe filters that have been added to our range of syringe filter. 

HILIC Column Speeds Analysis of Anti-Cancer Chemotherapy Drug

  
  
  
  
  
  
impurity analysis in pharmaceuticals

Adding to our large library of chromatography pharmaceutical applications on this blog, I am pleased to feature an application note describing a simple and rapid HPLC method for the determination of decitabine and its α-anomer impurity. Decitabine (link to Wikipedia page) is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug and is used in the treatment of acute myeloid leukemia and myelodysplastic syndromes.

HPLC Column for Wide Variety of Pharma Counterions Released!

  
  
  
  
  
  
pharma counterion analysis

I am very pleased to feature a newly released mixed-mode HPLC column (Thermo Scientific Acclaim Trinity P2 column) that has been designed to screen a wide range of pharmaceutical counterions, cations, anions, mono- and multi-valent ions in a single analysis!

Glycan Analysis Guide, On-Demand Webinar, & More

  
  
  
  
  
  
glycoproteomics research

Regular readers of this blog will know that I enjoy featuring useful reads and tools that help our readers in their work, and this roundup post featuring several resources for glycan analysis meets all my criteria for a useful read!

HILIC HPLC Column Selection Technical Note

  
  
  
  
  
  
HILIC method development

The technical note featured in this blog post describes a comparative study of the HILIC stationary phases in 10 silica-based HPLC columns (links to columns at end of the post), including unmodified silica, amino, diol, anion-exchange, nanopolymer silica hybrid, zwitterionic materials, and porous graphite carbon column.

HILIC HPLC Stationary Phase Speeds Separation of Charged Glycans (2)

  
  
  
  
  
  
analysis of charged N-glycans

An earlier blog post on this topic, HILIC HPLC Stationary Phase Speeds Separation of Glycans (1), (link to blog post) featured two application notes plus a scientific poster using one of our latest mixed mode HILIC HPLC glycan columns (Thermo Scientific GlycanPac AXH-1 column) which provides the simultaneous separation of glycans by charge, size, and polarity. Soon after the release of the post, I received an email that there was another application note featuring the very same column that I had missed! Hence, here I am pleased to feature the third application using this HILIC HPLC glycan column.

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