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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Automating Sample Dilutions in Ion Chromatography Analysis

ion chromatography high salt samples analysis

Here, I am pleased to feature not one but two downloadable technical notes on the topic of ensuring column capacity is not exceeded when analyzing high-salt samples using ion chromatography!

Gas Chromatography Autosampler for Liquid Samples!


GC Headspace Automated Solution Increases Throughput in USP Method 467

USP Method 467 residual solvent testing

Those working in drug discovery, development, or drug testing are familiar with the challenges of using gas chromatography for US Pharmacopeia (USP) method 467 which details headspace GC procedures for identification, control and quantification of Class 1 and 2 residual solvents. 

Gas Chromatography Solution for Residual Solvents in Pharmaceuticals

headspace gas chromatography

I am pleased to present, in today's post, the details of a newly released gas chromatography (GC) solution featuring the use of the headspace GC technique for the qualitative and quantitative analysis of residual solvents in pharmaceutical products in accordance with US Pharmacopeia (USP) Method <467> (link to USP webpage). For those new to pharmaceutical analysis, USP Method <467> describes how to identify and quantify any organic volatile solvent present in pharmaceuticals and excipients as a result of the pharma production process.

The solution consists of our latest headspace autosampler (Thermo Scientific TriPlus 300 HS valve-and-loop headspace autosampler), our fully modular gas chromatograph (Thermo Scientific  TRACE 1300 Series Gas Chromatograph), and our chromatography software (Thermo Scientific Dionex Chromeleon 6.80 SR13 CDS software) and provides an integrated and reliable platform with full auditing capabilities to perform high-capacity pharmaceutical analysis as per USP Method <467>.

SPE-LC-MS/MS Determination of Pregabalin in Human Plasma

hplc analysis of pregabalin gabapentin

Soon after a recent research story on the anti-convulsant prescription drug pregabalin which said the drug had failed to stop neuropathic pain as a result of HIV or diabetes (link to story) crossed my desk, I received an email about a new simple, rapid and sensitive liquid chromatography-tandem mass spectrometry application for the bioanalysis of pregabalin (link to NIH site on the drug) in human plasma! Pregabalin is used to treat neuropathic pain as a result of damaged nerves from diabetes, shingles, and dibromyalgia among other conditions.

Gas Chromatography: Analysis of Residual Solvents in Pharma Products

Residual Solvents in Pharma Products

After some of the recent posts on pharmaceutical analysis, this one crossed my desk and I thought it interesting enough to write about and add to the growing number of chromatography applications for pharmaceutical analysis on this blog. This new gas chromatography (GC) method was developed by our analytical chemists in our Milan office in Italy for the analysis and quantifying of residual solvents in pharmaceutical products and excipients as a result of the production process specified in the U.S. Pharmaceutical Method <USP> 467 (link to method). In this method, concentration limits are set for each solvent, and 53 solvents are analyzed and grouped according to their health hazards, including Class 1 (most toxic and unacceptable), Class 2 (associated with less severe toxicity), and Class 3 (less toxic).

The chemists used our new valve-and-loop autosampler system (Thermo Scientific TriPlus 300 Headspace Autosampler) that simplifies headspace analytical methods, and when combined with our Chromatography Data System (CDS) software (Thermo Scientific Dionex Chromeleon CDS software) to develop the method which meets the analytical requirements of the USP Method 467 with full auditing capability.

Chromatography Vial and Closure Products: Complimentary Posters

chromatography vials and closures

This is one of my favorite type of blog posts: a useful compliementary giveaway that be used by chromatographers for quick reference and thus making their jobs easier!

Chromatography Vial Closures Improved: Get a Test Sample

vial closures

I recently sent out an announcement about our new vial closure systems and then realized perhaps our blog readers would probably love to try one out for free and not just take us at our word on how much better sealing the new closures provide! (Details on how to order your sample are below.)

Ion Chromatography Combines Titration for Automated Water Analysis

titration ion chromatography

I am really pleased to feature our recently released  combined Titration/Ion Chromatography (IC) system for the testing of drinking, surface, or ground water. This new system combines titration with IC analysis for a completed analysis in as quickly as 20 minutes!

HPLC & Fluorescence Detection: Fast Analysis of Aliphatic Amines in Air

Aliphatic Amines Analysis

This blog post features a new application for an area constantly in the news: toxic air pollution. Stories in recent weeks have ranged from air pollution being linked to chronic heart disease, studies saying that the pollution from open-fire cooking may affect child cognitive development, and a USC study that says short-term reductions in air pollution in Beijing dramatically improved health! (Actually, just googling the words "toxic air pollution" brings up almost 10 million results.)

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