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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Ion Chromatography Analysis of Impurities in Drug Lithium Carbonate

  
  
  
  
  
  
lithium carbonate analysis

Here, I am pleased to present a recently developed fast ion chromatography method for the  simultaneous determination of lithium, sodium, and calcium in the drug lithium carbonate (link to U.S. National Library of Medicine) without the handling hazardous reagents.

HPLC Method for Metabolite Profiling of Wine, Juice, & Tea

  
  
  
  
  
  
metabolite profiling of tea wine fruit juice

I am pleased to present a recently released application note featuring a gradient HPLC method to study product authenticity, such as differentiating wine varietals, orange juice varietals and growing region, and distinguishing tea blends, and identifying adulteration in juices, such the blending of orange juice with cheaper juices or the inclusion of peel or pulp wash.

HPLC & CAD: Surfactants and Emulsifiers Applications Notebook

  
  
  
  
  
  
analysis of emulsifiers and surfactants using hplc

Did you know that the global food emulsifiers market is one of the fastest growing markets in the food ingredient market and is estimated to grow to $2,858.6 million by 2018? (Link to market research website.) Emulsifiers are used to stabilize emulsions in the food industry plus used as an additive to reduce fat content. Surfactants are compounds that lower the surface tension between liquids or a liquid and a solid, and are used as detergents, wetting agents, emulsifiers, foaming agents, and dispersants. (Definition and link Wikipedia page.) Other important uses of surfactants include industrial applications in lubrication, textile processing, petroleum recovery, and wastewater treatment.

GC-MS Analysis of Pesticides: Downloadable e-Book!

  
  
  
  
  
  
analysis of pesticide residues GC–MS

I am so pleased to offer you this new 52-page interactive e-book, developed by LCGC, on the advances in the analysis of pesticide residues using gas chromatography–mass spectrometry (GC–MS) methods.

HPLC Applications Notebook: Traditional Chinese Medicine

  
  
  
  
  
  
Traditional Chinese Medicine HPLC analysis

Did you know that the oldest work on Traditional Chinese Medicine (TCM) appeared in 200 B.C. and that the first TCMs and acupuncture needles appeared around 2500 BCE in China? (Link to site.) And, here I am pleased to present to you our recently released notebook featuring HPLC applications for TCM to help ensure the efficacy, purity and safety of these traditional remedies!

Electrochemical Detection Troubleshooting

  
  
  
  
  
  
troubleshooting Electrochemical Detection (ECD)

I came across two technical notes on troubleshooting Electrochemical Detection (ECD) problems, featured in this blog post, while reading up on a recently released HPLC application that used this type of detection. And, soon after, I found a poster note on the topic and thought this would make for a useful read for those working in HPLC-ECD applications. For those new to this type of detection, ED is the most sensitive and selective mode of LC detection for the measurement of oxidizable or reducible compounds.

Ion Chromatography: Bromide Analysis in Hydraulic Fracturing

  
  
  
  
  
  
analysis of fracking water

I have written about our ion chromatography solutions for fracking in earlier posts (listed below) but while reading about some water analysis applications on our website, I came across a really interesting white paper on the analysis of bromide in fracking water that I am pleased to feature in this blog post. I am sure you have following the debate on the safety of fracking around the globe; just recently scientists in the province of Nova Scotia in Canada being the latest to weigh in by calling in for a 10-year moratorium on hydraulic fracturing (link to news story).

Scaling Down Sample Extraction for Limited & Volatile Sample Volumes

  
  
  
  
  
  
bioanalysis sample preparation

In an earlier post on the use of our recently released solid-phase extraction (SPE) micro elution plates (Thermo Scientific SOLAµ Solid Phase Extraction [SPE] Well Plates) for bioanalysis, I covered how these well plates can enhance sample concentration by 20X (link to post), and here I am pleased to present an application note on how these plates can be used to facilitate the scale down of an extraction method for use when sample volume is limited or volatile as in the case of bioanalytical samples.

Chromatography Analysis of Additives & More in Beverages (II)

  
  
  
  
  
  
analysis of additives in beverage

After last month's post featuring chromatography applications for the analysis of sugars and artificial sweeteners in beverages (link to post), I am pleased to present two more application notebooks for the analysis of beverages, one for the analysis of carbonated beverages and the other for the analysis of additives in beverages.

Creating An HPLC Affinity Titer Column for Monoclonal Antibody Analysis

  
  
  
  
  
  
monoclonal antibody analysis

In the poster presented in this blog post, scientists from our Sunnyvale (USA) research lab describe a straightforward method for creating designer assays for QC analysis of monoclonal antibodies (mAb) using our HPLC-compatible, streptavidin-coated monolith column. This affinity column produces narrow concentrated peaks with minimal diffusion, allows for titer analysis over a wide concentration range, and is applicable for a range of applications from small-scale protein to antibody titer analysis.

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