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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Glycan Analysis with a Particular Focus on the Immune System

  
  
  
  
  
  
Human Immune System attack a virus

As an immunologist and analytical scientist, I have always been fascinated with the immune system and how pathogens and the immune system have evolved hand-in-hand as the former seeks new ways to avoid and disguise itself from the latter and the immune system develops alternative mechanisms to seek out and destroy invading pathogens. It’s a miniature arms race occurring inside each and every one of us, but only really becoming noticeable to us when we feel the effects of the raging battle through illness. I do believe that the immune system represents a model and spell-binding system in which to view evolution occurring, although my young children would probably disagree and much prefer an alternative bedtime story to one of my favorite books for children, titled, Your Amazing Immune System! (details of how to get a free copy of this book if you wish to go with the immunological children’s bedtime story.)

GC-MS/MS Identification of Biomarkers Improve Rice Crossbreeding

  
  
  
  
  
  
analysis of rice biomarkers

After Paul Dewsbury's informative and educational blog post, ICP-MS Arsenic Speciation in Rice: The Media and The Science, (link to post), I came across a recently released application for the identification and quantitation of biomarkers in rice for improving crossbreeding that I found fascinating for several reasons. One is because rice is one of my favorite foods in all its forms ranging from simple steamed rice to complex South Asian biryanis and I enjoy it in pretty much any cuisine that I have encountered it; second, the importance of rice as a nutritional source for humans; and third, the application itself.

How Much Hydraulic Fracturing Wastewater Analysis Do We Need?

  
  
  
  
  
  
hydraulic fracking water analysis

Hydraulic fracturing (commonly called fracking) has been a hot topic for several years. In many cities, fracking issues were on the latest election ballots (link to a recent article in Newsweek). Many environmental conservationists wanted their concerns about fracking heard by their new elected officials, while campaign candidates were eager to promise they would address the need for environmental regulations.

Ready-To-Go Qualification Tools for Trace Metals in Pharma Analysis

  
  
  
  
  
  
compliance for USP 232 233

It’s appropriate I am writing this blogpost in December 2014; exactly one year away from the start of new regulation from U.S. Pharmacopeial Convention (USP) that mandates the testing of fifteen trace elements (metals) in pharmaceutical products from 1st December 2015 onwards as per USP <232> & <233> (link to USP site on these regulations).

So, the clock is now ticking towards this date and I’m meeting nutraceutical, pharmaceutical, and biopharmaceutical manufacturers across the globe that are making preparations to meet these new pharmaceutical regulations.

Hydrophobic Interaction Liquid Chromatography: Sorting Through the Hype

  
  
  
  
  
  
Hydrophobic Interaction Liquid Chromatography or HILIC

In my 25 years in the chromatography industry, I have seen tremendous improvements in daily laboratory workflow through the years, in many cases, due to revolutionary products developed to save time and money for the researcher and provide more accurate and reproducible results day after day.  I know how difficult it is to stay current and sort through all the new developments in the industry especially while you’re trying to execute daily activities.  There is little time to explore all the new tools and techniques presented, and it’s hard to know which ones will benefit you. My goal, in this and future blog posts, is to discuss and provide resources on the latest tools and techniques that will help you improve and speed up your day-to-day work in the lab.

Is Your Wine Authentic: An Ion Chromatography Method

  
  
  
  
  
  
authenticating wine

On the agenda of the recent UK Laboratory of the Government Chemist (LGC) meeting I attended was a fascinating talk titled: Wine Fraud – Catching the Cheats (link to downloadable pdf of the talk) by renowned wine expert Geoff Taylor (link to profile) of Campden BRI. Although Geoff’s does not discuss Ion Chromatography (IC), his abstract has some startling facts where fraud could potentially make serious money for the criminals, ranging from the fine wine market where volume is low and unit prices are high through to the mass volume market.

These are a Few of My Favorite (Chemistry) Things

  
  
  
  
  
  
chemistry cookie cutters

It’s the beginning of the holiday season so what better time to share some ideas that would make fun gifts for the chemist in your life. No bright copper kettles or warm woolen mittens on this list, though.

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HPLC Conference Overload & Fractal Chromatography Columns

  
  
  
  
  
  
hplc protein peptide analysis

I occasionally get conference overload, and this was the case a few months ago with three chromatography conferences in two weeks (HPLC 2014, ISCC at Riva, and the UK ChromSoc AGM), two oral presentations and five posters to present plus the many seminars given by other delegates to listen to as well. It sounds busy and it is intensive as most of the hard work comes from the interactions outside of the lecture halls.

Overcoming Interference Challenges During Trace Elemental Analysis

  
  
  
  
  
  
trace elemental interference in ICP-OES, ICP-MS, ICP-MS analysis

Applications for trace elemental analysis are quite common, ranging from toxic metal analysis in water, lead analysis in toys, to trace metals analysis for semiconductor, with detection level requirements ranging from parts per million (ppm) to sub parts per trillion (ppt). The trace contamination of certain elements can lead to severe health problems or cause defect in products.

ICP-MS Arsenic Speciation in Rice: The Media and The Science

  
  
  
  
  
  
quantification of inorganic arsenic in rice

Recently I watched a very thought provoking documentary by Dispatches on Channel 4 here in the UK which was all about arsenic in rice and rice products (link to U.S. FDA page). As I have a keen interest in ion analysis, I was intrigued to see if the science is consistent with the media story, so took on some research of my own.

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