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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Importance of Solvent Quality in UHPLC & HPLC Analysis

hplc solvent quality

I am pleased to present a recently released technical note on how to optimize and monitor the quality of your solvents when using UV-Vis absorption, fluorescence detection, or charged aerosol detection with HPLC or UHPLC.

Accelerated Solvent Extraction & UHPLC Analysis of Mangosteens

HPLC analysis of xanthones

The fascinating UHPLC study in this blog post was presented at the recent Pittcon conference and presents a fast extraction method using Accelerated Solvent Extraction (ASE) which requires only 30 mins and provides >96% recovery with excellent reproducibility!

Ion Chromatography Improves Chromium Speciation in Drinking Water

chromium in drinking water infographic

Did you know that new laws for measuring chromium in water are on the horizon and, in particular, hexavalent chromium (Cr6+) is under evaluation for new legislation by the U.S. EPA (link to US EPA page on recommendations for Cr6+ monitoring) and the European EFSA (link to EFSA Scientific Opinion page on Cr6+). 

HPLC Drug Analysis Columns Proposed in USP New & Revised Monographs

hplc columns for drug analysis

I know this post might come across as a bit of a puff piece (promotional piece) but when I received the two emails announcing the various HPLC columns that have been proposed for use in United States Pharmacopeia’s (USP) Pharmacopeia Forum (link to site) monographs for the analysis of pharmaceuticals, I was a bit thrilled and wanted to share the good news with our blog readers.

Ion Chromatography Column: Improved Analysis of Small Polar Amines

ion chromatography column

This blog post features a recently released ion chromatography column for the analysis of smal polar amines (Thermo Scientific Dionex IonPac CS19-4µm column) that uses smaller resin particles which results in more efficient peaks for the fast separation of inorganic cations, polar amines and moderately hydrophobic amines.

Accelerated Solvent Extraction in Toxicology Research Studies

sample preparation chromatography

This blog has previously featured the use of Accelerated Solvent Extraction (ASE) as an efficient, cost saving, and fast sample preparation technique in animal science, geoscience, environmental biology, and climate research research studies and, I believe, this may be the first post featuring toxicology research studies using ASE as a sample preparation technique.

UHPLC and HPLC Methods for Improved Analysis of Peptides

peptide analysis by HPLC

The interesting poster presented in this blog post was presented at the recent Pittcon conference and it describes the development of UHPLC and HPLC electrochemical detection (EC) methods for the measurement of different cystine-containing peptides including simple peptides (glutathione), medium-sized peptides (insulin), cyclic peptides (oxytocin and vasopressin) and peptides with cystine knots (cyclotides). (Image accompanying this post is of an insulin molecule.)

Ion Chromatography: Analysis of Choline in Infant Formula Updated!

ion chromatography

I am pleased to feature an updated ion chromatography method to more easily determine total choline (free and bound forms) in 17 samples representing all forms of infant formula, adult nutritionals, and pediatric formulas (powder, ready-to-feed products, and liquid concentrates).

Chromatography Vial Identification System Launched!

chromatography vial labeling

I am pleased to feature our recently released chromatography vial labeling and identification system (Thermo Scientific Virtuoso Vial Identification System) designed to eliminate costly labeling errors and boost productivity!

Question for LIMS Users: Are You Optimizing Your Investment?

lab informatics systems

Remind yourself what that laboratory software is there to do - and attend a complimentary one-day event with industry professionals in the UK, London, Thursday May 1.

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