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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Breeding Program & Pesticides Use Propel Strawberries to Celebrityhood

  
  
  
  
  
  
pesticides strawberries

Strawberries are well on their way to becoming California’s newest celebrity as indicated by the two strawberries-related stories that have been much in the news in California this year. First, there have been serious disagreements between a university and the scientist running the university’s strawberry breeding program to the extent of the media labeling it as a feud (see links to stories below). The second debate formed around the use of certain pesticides in California. This led to California’s Department of Pesticide Regulation establishing the the nation’s strictest limits on chloropicrin, a pesticide commonly injected into soil before strawberries are planted. (Links to the California Department of Pesticide Regulation page and their chloropicrin page.) Both stories are causing much interest and concern in the strawberry-growing community.

Rapid Fruit Juice Analysis: A Case Study at the J.M. Smuckers Co.

  
  
  
  
  
  
analysis of glucose, fructose, and sucrose in jams purees

What does it take in terms of process analysis and control to manufacture jams, purees, and fruit juice from fresh, sweet summer fruits? Historically, wet chemistry methods have been been used to analyze raw materials and fruit juice products in a manufacturing setting, but this is a slow tedious process and for labs requiring a high turnover of samples is not efficient or timely.

The European Bioanalysis Forum: What’s Going on With Antibodies?

  
  
  
  
  
  
antibody conference in barcelona

This week I encountered the power of nature. Because of weather on the East coast of the USA, my flight was cancelled and I missed a conference I planned to attend in Washington DC about the characterization of biotherapeutics. I really hope that the majority of attendees manage to make it.

Your Elemental Analysis is Costing You More Than You Think: Part 1

  
  
  
  
  
  
inductively coupled plasma optical emission spectrometry

In this three-part series blog post on trace elemental analysis, I will discuss key focus areas for a laboratory intent on maximizing its productivity and improving its profitability. In this first post, I will discuss the use of a switching valve to conduct elemental analysis and describe the use of a segmented stream during sample analysis and highlight its advantages over those when a continuous flow stream is employed. 

Why I Turned from Phosphorylation to Glycan Analysis

  
  
  
  
  
  
glycosylation analysis by UHPLC

Most of my early research career focused on the post-translational modifications (PTMs) of proteins and in those days there was only one worthy PTM in my eyes and that was phosphorylation while glycosylation hardly registered. That was because phosphorylation governed important cellular processes (in my view at least) such as cell signalling; however, my love of phosphorylation slowly waned as I grew to understand the only reliable method to measure phosphorylation was with the potentially harmful radioactive Phosphorus-32 (32P)! (Link to Wikipedia page.) That’s when I started to get more interested in glycosylation and the huge diversity of modifications this could entail, after all phosphorylation was only adding phosphate on to a serine, threonine or tyrosine. Glycosylation offered more possibilities and intrigue and the opportunity to use other analytical techniques that didn’t involve 32P.

Give Your Valentine: Antioxidants!

  
  
  
  
  
  
analysis of polyphenols in wine

Of all the special days on the calendar, I think Valentine’s Day has to be the healthiest. Think about it. Christmas has all those fattening cookies, fruitcake, and candy canes – not to mention the stress of shopping, wrapping, and paying off the credit cards. Thanksgiving is known for overeating and has pies, pies, pies. Halloween? Please. The Fourth of July is grilled meat (HCAs and PAHs anyone?) and ice cream. But Valentine’s Day is red wine, chocolate, and flowers.

Why Attend an International Symposium on Pesticide Analysis?

  
  
  
  
  
  
pesticides analysis conference in prague

After reading the title of this post, perhaps you are wondering to yourself: Why organize yet another meeting on analysis of pesticides? Firstly, this two-day symposium, titled, 1st International Symposium on Recent Developments in Pesticides Residues Analysis, (link to symposium registration page), is intended to complement other well-established workshops, such as, EPRW and LAPRW. We are organizing the symposium to provide a platform for our customers to discuss robust, fit-for-purpose routine applications and the use of emerging technologies for the development of new and future workflows. In particular, we will present the further advancements, such as increased speed, higher resolving power, and improved analysis quality, of our Orbitrap technology for both targeted and screening pesticide analysis plus we will also be covering topics, such as sample preparation, GC-MS/MS, LC-MS/MS and IC-MS/MS and the latest in software advances to help with data interpretation and reporting.

Gas Chromatography Consumables: Tips for Best Results

  
  
  
  
  
  
gas chromatography consumables

In my last two installments in this series, I covered Hydrophobic Interaction Liquid Chromatography (link to blog post) and Sample Preparation: Three Techniques Reviewed (link to blog post); and here, I would like to provide you with some helpful tips and references on how to select the correct gas chromatography (GC) consumable for your experiment.

Elemental Speciation for Environmental Testing: Spotting the Bad

  
  
  
  
  
  
chromium and arsenic speciation using IC-ICP-MS

After my last two posts on dealing with the challenges of interference in trace elemental analysis (link to post) and an overview on the analysis of fracking wastewater (link to post), I thought I would turn my attention to discussing elemental speciation in this post.

The Smell of a New Car can be Revealed by Thermal Desorption GC-MS

  
  
  
  
  
  
analysis of vocs in car

When I am fortunate enough to buy a new car, one of my pleasures in the new car is the pure joy of sitting inside it and smelling that lovely mix of luxury and brand-new materials. Have you ever wondered what that new car smell is actually? Well, you’re in luck, as in this post, I will present a recently released thermal desorption GC-MS method for the analysis of air in new cars but also talk a little about legislations around the globe to monitor and control the air quality inside a new car plus if these emissions are safe.   

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