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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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Ion Chromatography Speeds Hydraulic Fracturing Wastewater Analysis

hydraulic fracturing wastewater analysis

Did you know that hydraulic fracturing (also called fracking) has been used in the United States since the late 1940s and it is estimated that there are over one million wells hydraulically fractured in the last 60 years in the U.S.? (Source & link EnergyFromShale). In addition, fracking has seen a profound growth due to new capabilities that permit recovery of oil and natural gas from previously inaccessible deposits.

Accelerated Solvent Extraction: Organochlorine Pesticides in Oysters

sample preparation oyster tissue

Here, I am pleased to feature an improved and fast sample preparation method for challenging matrices, such as a wet animal tissue, for example an oyster sample using our latest dispersant and sorbant copolymer. This polymer was featured in a blog post some weeks ago: Accelerated Solvent Extraction: New Polymer for Wet Samples (link to post).

Gas Chromatography Headspace Analysis of Residual Solvents

analysis of solvents in food packaging

I am pleased to feature a recently released automated gas chromotography method for the analysis of residual solvents in flexible packaging material used for food that not only easily meets the requirements of the European Standard absolute method EN 13628-1: 2002 standard but also provides excellent quantitation results without any sample preparation! (By the way, if you are new to food testing, EN 13628-1: 2002 is the British standard for determining residual solvents by static headspace gas chromatography and applies to flexible packaging materials that consist for mono- or multilayer plastic films, paper or board, foil or combinations thereof.)

Hydrophobic Interaction Chromatography Method for MAb Analysis

analysis of papain digests

I am pleased to feature one of our hydrophobic interaction chromatography (HIC) columns (Thermo Scientific ProPac HIC-10 column) in a newly released method describing the separation of low-concentration species of an intentionally oxidized monoclonal antibody (MAb) from the native MAb. Those working in the field of developing MAbs as human therapeutics are fully aware of the challenges of working with MAbs, which can include various post-translational modifications and degradation during storage and delivery.

HPLC Speeds Determination of Dicyandiamide in Milk Powder

dicyandiamide analysis in milk powder

Here, I am pleased to feature an efficient and simple reliable HPLC method for the monitoring of dicyandiamide levels in milk and milk-derived products; last year, a New Zealand company found traces of this toxic chemical in its milk products (link to story).

UHPLC-MS Analysis of Psychotropics in Mushrooms and Chocolate

Psychotropics in Mushrooms and Chocolate

I found this fascinating application, featured here, presenting an UHPLC-MS method for the analysis of the psychotropic substances psilocybin and psilocin in mushrooms and chocolate on our website while looking for information on one of our UHPLC systems and thought it would make a great read on this blog! The method was developed by our chemists at our San Jose lab (California, USA) in collaboration with the Crime Laboratory of the Washington State Patrol (Washington, USA) to aid in the identification of controlled substances, such as psychotropics, in small quantities of seized evidence.

HPLC Solution Kit for Simultaneous Analysis of Pharma Counterions

hplc counterion analysis

I am pleased to present our recently released HPLC counterion solution kit for pharmaceutical QA/QC (Thermo Scientific IonCount solution) which simplifies the analysis and setup of complete HPLC workflows for common and less common organic and inorganic counterions in pharmaceutical analysis. Those working in this field know that obtaining qualitative and quantitative information of pharmaceutical drugs and residual salts is critical for determining the purity, mass balance and stoichiometry of drug formulations and this solution can speed up the screening and assaying of a broad variety of counterions and active pharmaceutical ingredients (APIs).

Chromatography and Sample Preparation Terminology Guide

chromatography terminology

In this very short blog post, I wanted to provide a link to a great resource, Advanstar Science's Chromatography and Sample Preparation Terminology Guide (link to page where you can click Register, fill out a brief form and then download the guide).

Accelerated Solvent Extraction: Fast Extraction of Fat in Snack Foods

fat determination in snacks

Reading this application update on a faster sample preparation method for the extracting total unbound fat from packaged foods, I learned that many regulatory agencies, such as the US FDA, the Food Safety and Standards Authority of India, UK's Dept for Environment, Food & Rural Affairs, and the Australia New Zealand Food Standards Code, require that the nutritional content including fat in processed and packaged food is declared on the product label. (Links open labeling regulatory pages or PDFs.)

Ion Chromatography: Municipal Water Analysis Applications Notebook

Municipal Water Analysis Applications

Did you know that the state of California in the USA is heading into year three of its worst drought of 40 years? (Link to story.) Experts in the state are looking at efficiencies and reuse of water sources, such as agricultural and urban water, water reuse and recycling, and increased capturing of local rainwater.

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