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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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HPLC & Charged Aerosol Detection Analysis of Emulsifiers in Foods

  
  
  
  
  
  
emulsifier analysis using HPLC

Recently, I received an email highlighting presentations and posters presented at Pittcon 2014, and my attention was caught by the poster presented in this blog post. Developed by researchers at our Chelmsford Center of Excellence (USA), the poster presents the development of two HPLC methods for the quantitation of emulsifiers in foods, namely lecithin commonly used in chocolate and spray oils, and hydroxypropylmethyl cellulose (HPMC) used to thicken dairy products and help improve flavor characteristics plus used in pharmaceutical formulations.

HPLC Determination of Growth Stimulants in Farm Animals

  
  
  
  
  
  
fast HPLC analysis of clenbuterol, ractopamine, and phenolethanolamine in meat

This blog post features the efficient and sensitive HPLC analysis of the synthetic compounds clenbuterol, ractopamine, and phenolethanolamine which have been extensively used as growth stimulants in farm animals (and by athletes seeking enhanced performance). The reason for concern is that these compounds, grouped as e β2-agonists, may remain as residues in meat intended for human consumption. While food safety concern for the presence of ractopamine is low, high levels of clenbuterol can cause severely increased heart rate and blood pressure, anxiety, palpitation, and skeletal muscle tremors. (Source & link: Centre for Food Safety in HongKong.) Clenbuterol has been banned by many countries including the USA, European Union, and China; and, the newly introduced phenolethanolamine is already banned in China.

Ion Chromatography Determination of Benzene Sulfonic Acid Counterion

  
  
  
  
  
  
ion chromatography pharma analysis

Did you know that there is currently no United States Pharmacopeia (USP) method for determining the benzene sulfonic acid counterion in the drug substance amlodipine besylate, a calcium channel blocker used for the treatment of hypertension and angina? And, hence, I am pleased to present a reliable, sensitive, and selective ion chromatography method for the determination of the counterion in this blog post!

GC-MS Bioanalysis Research Studies

  
  
  
  
  
  
gas chromatography bioanalysis

I just realized it has been a while (actually more than a month) since I have featured a gas chromatography application on this blog, and here I am pleased to present four bioanalysis research studies, all featuring the use of our latest gas chromatography solutions for the analysis.

Importance of Solvent Quality in UHPLC & HPLC Analysis

  
  
  
  
  
  
hplc solvent quality

I am pleased to present a recently released technical note on how to optimize and monitor the quality of your solvents when using UV-Vis absorption, fluorescence detection, or charged aerosol detection with HPLC or UHPLC.

Accelerated Solvent Extraction & UHPLC Analysis of Mangosteens

  
  
  
  
  
  
HPLC analysis of xanthones

The fascinating UHPLC study in this blog post was presented at the recent Pittcon conference and presents a fast extraction method using Accelerated Solvent Extraction (ASE) which requires only 30 mins and provides >96% recovery with excellent reproducibility!

Ion Chromatography Improves Chromium Speciation in Drinking Water

  
  
  
  
  
  
chromium in drinking water infographic

Did you know that new laws for measuring chromium in water are on the horizon and, in particular, hexavalent chromium (Cr6+) is under evaluation for new legislation by the U.S. EPA (link to US EPA page on recommendations for Cr6+ monitoring) and the European EFSA (link to EFSA Scientific Opinion page on Cr6+). 

HPLC Drug Analysis Columns Proposed in USP New & Revised Monographs

  
  
  
  
  
  
hplc columns for drug analysis

I know this post might come across as a bit of a puff piece (promotional piece) but when I received the two emails announcing the various HPLC columns that have been proposed for use in United States Pharmacopeia’s (USP) Pharmacopeia Forum (link to site) monographs for the analysis of pharmaceuticals, I was a bit thrilled and wanted to share the good news with our blog readers.

Ion Chromatography Column: Improved Analysis of Small Polar Amines

  
  
  
  
  
  
ion chromatography column

This blog post features a recently released ion chromatography column for the analysis of smal polar amines (Thermo Scientific Dionex IonPac CS19-4µm column) that uses smaller resin particles which results in more efficient peaks for the fast separation of inorganic cations, polar amines and moderately hydrophobic amines.

Accelerated Solvent Extraction in Toxicology Research Studies

  
  
  
  
  
  
sample preparation chromatography

This blog has previously featured the use of Accelerated Solvent Extraction (ASE) as an efficient, cost saving, and fast sample preparation technique in animal science, geoscience, environmental biology, and climate research research studies and, I believe, this may be the first post featuring toxicology research studies using ASE as a sample preparation technique.

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