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A blog on the latest applications, articles, & research on chromatography solutions in sample preparation, Ion Chromatography (IC),
High Pressure Liquid Chromatography (HPLC), Ion Chromatography-Mass Spectrometry (IC-MS), Gas Chromatography (GC),
Gas Chromatography-Mass Spectrometry (GC-MS and GC-MS/MS), and software (Chromeleon CDS, LIMS, and ProteinCenter).

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HPLC Speeds Analysis of 21 Preservative Componds in Cosmetics

Analysis of Preservatives in Cosmetics

After the last post on the HPLC analysis of the toxic chemical rhodamine B in cosmetics (link to post), toxic chemicals in makeup have been on my mind a bit; and, when I found the application blogged here, I read it with great interest as it presented the analysis of preservatives, no less than 21 of them, in personal care products!

HPLC Method for Determination of Benzo(a)pyrene in Meat Products

Benzo(a)pyrene in smoked meat

Here, I am pleased to present an efficient HPLC method featuring an improved sample preparation method with fluorescence detection for the sensitive and rapid determination of benzo[a]pyrene (downloadable U.S. EPA factsheet) in complex meat products, such as sausages and preserved ham. 

Gas Chromatography Environmental Microbiology Research Studies

gc-ms in microbiologyThe three peer-reviewed, environmental microbiology research studies presented briefly in this post all use our gas chromatography-mass spectrometry solutions for their research but I must admit that methane and bacteria came to my mind after I read these fascinating research stories tweeted by our Chromatography Solutions Twitter account (link to account):


Trust Your LIMS and Leave the Paper Behind in the R&D Lab


With fewer dollars to go around for R&D and increasing production costs, the life sciences industry must root out inefficiencies wherever possible and build in new processes to achieve improved productivity and greater efficiencies across an oftentimes much broader organization, starting with the laboratory. New technologies help accelerate discovery, which adds complexities that now-smaller staffs must manage.  Never has the need for comprehensive enterprise-wide information management and analysis been greater. A highly integrated Laboratory Information Management System (LIMS) can open the doors to new R&D investment.

HPLC Speeds Analysis of Rhodamine B in Cosmetics

analysis of cosmetics

I was fascinated by the HPLC application described in this post as it deals with chemicals, in particular Rhodamine B, (link to Wikipedia page), in cosmetics, and I am always curious to know what could be lurking in cosmetics that I might be using. Many regulatory bodies around the globe, such as the U.S. FDA (link to cosmetic labeling guide), European Commission (link to EU regulations on cosmetics), India's Bureau of Standards (link to regulations for cosmetics), and China's Food and Drug Administration (link to cosmetics regulatory pages) regulate the ingredients, testing, and labeling of cosmetics.

HPLC & CAD: Separation of Biochemical Buffering Agents

analysis of buffering agents

Good’s buffers are a series of 20 zwitterionic buffering agents that are used in biochemical experiments and HPLC mobile phases and feature stable pH control, low biological activity, low UV absorbance, and low metal affinity. This post features a newly released method separating 22 of these and other common buffer ingredients by simultaneous anion exchange (AEX), cation exchange (CEX), and hydrophilic interaction chromatography (HILIC) with simple isocratic conditions.

Ion Chromatography Speeds Hydraulic Fracturing Wastewater Analysis

hydraulic fracturing wastewater analysis

Did you know that hydraulic fracturing (also called fracking) has been used in the United States since the late 1940s and it is estimated that there are over one million wells hydraulically fractured in the last 60 years in the U.S.? (Source & link EnergyFromShale). In addition, fracking has seen a profound growth due to new capabilities that permit recovery of oil and natural gas from previously inaccessible deposits.

Accelerated Solvent Extraction: Organochlorine Pesticides in Oysters

sample preparation oyster tissue

Here, I am pleased to feature an improved and fast sample preparation method for challenging matrices, such as a wet animal tissue, for example an oyster sample using our latest dispersant and sorbant copolymer. This polymer was featured in a blog post some weeks ago: Accelerated Solvent Extraction: New Polymer for Wet Samples (link to post).

Gas Chromatography Headspace Analysis of Residual Solvents

analysis of solvents in food packaging

I am pleased to feature a recently released automated gas chromotography method for the analysis of residual solvents in flexible packaging material used for food that not only easily meets the requirements of the European Standard absolute method EN 13628-1: 2002 standard but also provides excellent quantitation results without any sample preparation! (By the way, if you are new to food testing, EN 13628-1: 2002 is the British standard for determining residual solvents by static headspace gas chromatography and applies to flexible packaging materials that consist for mono- or multilayer plastic films, paper or board, foil or combinations thereof.)

Hydrophobic Interaction Chromatography Method for MAb Analysis

analysis of papain digests

I am pleased to feature one of our hydrophobic interaction chromatography (HIC) columns (Thermo Scientific ProPac HIC-10 column) in a newly released method describing the separation of low-concentration species of an intentionally oxidized monoclonal antibody (MAb) from the native MAb. Those working in the field of developing MAbs as human therapeutics are fully aware of the challenges of working with MAbs, which can include various post-translational modifications and degradation during storage and delivery.

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